特征识别受体是固有免疫细胞感知危险的主要途径，主要包括 toll样受体 （TLR）， NOD-like receptor (NLR)， RIG-I-like receptor (RLR)， STING 等等。它起效快，不依赖于特异病原体。

NOD1 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing molecules containing D-glutamyl-meso-diaminopimelic acid (iE …

The nucleotide-binding oligomerization domain (NOD) proteins, NOD1 and NOD2, represent two well characterized PRRs of the NOD-like receptor (NLR) family that sense conserved fragments found in the cell wall of many types of bacteria and activate intracellular signaling pathways that drive pro-inflammatory and anti-microbial responses.

2024年12月25日 · NOD1 (Nucleotide Binding Oligomerization Domain Containing 1) is a Protein Coding gene. Diseases associated with NOD1 include Blau Syndrome and Hematologic Cancer. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and SARS-CoV-2 …

2013年12月13日 · NOD1 (nucleotide oligomerization domain-containing protein 1) and NOD2 are members of the NOD-like receptor family of proteins, which function to detect peptidoglycan and to stimulate host...

2022年3月22日 · NOD1 and NOD2 are two seminal NLRs that have been shown to sense specific bacterial ligands and have diverse immunomodulatory effects that are important for both host defense and tissue homeostasis.

2019年7月30日 · NOD1 and NOD2 are related intracellular sensors of bacterial peptidoglycan and belong to the Nod-like receptor (NLR) family of innate immune proteins that play fundamental and pleiotropic roles in host defense against infection and in the control of inflammation.

6 天之前 · Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells. Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies. Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate.

NOD1 is an intracellular pattern-recognition receptor belonging to the Nod-like receptors (NLRs) family, and recognizes γ-d-glutamyl-meso-diaminopimelic acid (iE-DAP) of peptidoglycan derived from invading Gram-negative bacteria (Kawai and Akira, 2011).

该基因编码核苷酸结合寡聚化结构域 (NOD) 样受体 (NLR) 蛋白家族的成员。 编码的蛋白质通过充当结合细菌肽聚糖并引发炎症的模式识别受体 (PRR) ，在先天免疫中发挥作用。 这种蛋白质还与对病毒和寄生虫感染的免疫反应有关。 这种蛋白质的主要结构特征包括一个 N 端半胱天冬酶募集结构域 (CARD) 、一个位于中心的核苷酸结合结构域 (NBD) 和位于其 C 末端的 10 个串联的富含亮氨酸重复序列 (LRR) 。 CARD 参与细胞凋亡信号，LRR 参与蛋白质-蛋白质相互作用，NBD …