NOF provides high-performance activated PEGs for PEGylated drugs from the early development stage to commercial use with over 20 years of experience in manufacturing high-quality methoxy polyethylene glycol.

NOF produces the world's best quality Activated PEGs from our high-quality methoxypoly (ethylene glycol) (mPEG). NOF also supplies our proprietary high-purity branched, multi-arm and hetero-functional Activated PEGs tailored to meet our customers' PEG Drugs.

NOF provides high-performance activated PEGs for PEGylated drugs from early development stage to commercial use with our 20 years of experience of manufacturing high-quality methoxy polyethylene glycol, which is a starting material of activated PEG for pharmaceutical area.

PEG phospholipids of the carbamate-linked type are resistant to hydrolysis, and therefore are used for commercial production of PEGylated liposomes. As NOF employs its own high-quality activated PEGs and phospholipids, high-quality PEG phospholipids can be supplied.

Key Features: Enhanced Stability: The PEG moiety of GM-020 forms a hydrophilic layer around LNPs, reducing aggregation and increasing stability in biological environments. Prolonged Circulation: Extends the half-life of LNPs in the bloodstream, improving bioavailability of the encapsulated therapeutic agents and therapeutic outcomes.

NOF provides high-performance activated PEGs for PEGylated drugs from early development stage to commercial use with over 20 years of experience of manufacturing high-quality methoxy polyethylene glycol.

Monofunctional Linear PEGs The mono-functional SUNBRIGHT® series comprising highly purified methoxy PEG as the starting material contains negligible bifunctional PEG derived from diol impurities. Accordingly, bridging reactions (side reaction), an obstacle to PEGylation, can be completely prevented.

日油グループは、「バイオから宇宙まで幅広い分野で新しい価値を創造し、人と社会に貢献します」を経営理念とし、1937年の創立以来、化学メーカーとして事業を多面的に展開しています。

日本油脂株式会社（NOF ） 提供用于药物递送系统（Drug Delivery Systems，DDS）构建、研发和生产用原料/产品及技术服务（表1），覆盖药物早期开发到商业使用阶段：

NOF has developed novel monodisperse PEG linkers that have pendant-like structure. The pendant type PEG linkers have two monodisperse PEG chains with two different functional groups. The pendant type PEG linkers can improve hydrophilicity of ADCs by effectively masking hydrophobicity of payloads.