Non-CLL-like MBL cases frequently show biclonality, in association with MZL-, LPL-, MCL-like, or unclassifiable phenotypic profiles. As with CLL-like MBL, the frequency of non-CLL-like MBL increases with age, with a clear predominance of males.

2015年7月23日 · Monoclonal B lymphocytosis (MBL) is defined as the presence of a clonal B-cell population in the peripheral blood with fewer than 5 × 10 9 /L B-cells and no other signs of a lymphoproliferative disorder. The majority of cases of MBL have the immunophenotype of chronic lymphocytic leukemia (CLL).

2024年11月5日 · Individuals with non-CLL-type MBL had significantly increased risk of lymphoid malignancies, similar to CLL-type MBL, but, distinct from CLL-type MBL, no evidence of an increased risk of melanoma. Our study provides insights into the prevalence, genetic predispositions and clinical consequences of non-CLL-type MBL and how it differs from the ...

2024年11月16日 · High-grade B-cell lymphoma not otherwise specified (HGBCL, NOS) has overlapping morphological and genetic features with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL), leading to uncertainty in its diagnosis and clinical management.

Monoclonal B cell lymphocytosis (MBL) is both a marker of immune senescence and a potential precursor of B cell malignancy. Most MBL populations have a chronic lymphocytic leukemia-like (CLL-like) immunophenotype, but those that are CD5-negative (non-CLL-like) are also recognized and may represent a …

2023年5月16日 · By employing the non-zero imaginary eigenenergies ratio, half-chain entanglement entropy, and eigenstate instability, we numerically confirm that the critical points of spectral real-complex (RC) transition and many-body localization (MBL) phase transition are not identical, and an examination of the phase diagrams reveals that the spectral RC ...

2011年11月18日 · Clinically, three patients developed splenomegaly and one patient progressed with lymphadenopathy. Unlike the findings from population screening, this study represents a series of clinical MBL of non-CLL phenotype, and our results indicate the heterogeneity in genetic changes and clonal progression.

The two most common non-CLL types are CD5 − MBL (classified as “non-CLL phenotype MBL”) and CD5 + MBL with a phenotype that is not typical for CLL, i.e. strong CD20, CD79b or immunoglobulin expression (classified as “atypical-CLL phenotype MBL”). Individuals with a CD5+, CD23 negative phenotype must have the diagnosis of mantle cell ...

2010年12月14日 · Monoclonal B-cell lymphocytosis (MBL) indicates <5 × 10 9 peripheral blood (PB) clonal B-cells/L in healthy individuals. In most cases, MBL cells show similar phenotypic/genetic features to chronic lymphocytic leukemia cells—CLL-like MBL—but little is known about non-CLL-like MBL.