Nonactin is a member of a family of naturally occurring cyclic ionophores known as the macrotetrolide antibiotics. The other members of this homologous family are monactin, dinactin, trinactin and tetranactin which are all neutral ionophoric substances and higher homologs of …

Nonactin | C40H64O12 | CID 72519 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

无活菌素（Nonactin），CAS NO. 6833-84-7， 分离自几种链霉菌属（Streptomyces sp.）代谢产物的一种环呋喃内酯类抗生素，特异性结合并转运K+和NH4+的单价阳离子载体（无活菌素-EVA传感器，K+= NH4+> Na+> Mg2+> Li+>> Ca2+）。正因其自身构象的灵活性和外部结构的疏水 …

Nonactin is a naturally occurring 32-membered macrocyclic tetraester compound that exhibits antimicrobial, antifungal, and insecticidal activity. It is the first crown ether to possess antibiotic properties and forms one-to-one complexes with alkali and alkaline earth metal ions, showing selectivity towards NH4+ and K+.

Nonactin is a polyketide antibiotic produced by Streptomyces griseus ETH A7796. It is active against a range of Gram positive organisms, acting as an ionophore that has a high selectivity for K + ions. Among the polyketides, nonactin has a unique structure.

Nonactin is the parent compound of a group of ionophore antibiotics, known as the macrotetrolides, produced by Streptomyces griseus subsp. griseus ETH A7796. Nonactin is a significant compound because of its inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.

2002年3月1日 · Nonactin is a macrotetrolide antibiotic produced by Streptomycesgriseus subsp. griseus ETH A7796 that has shown activity against the P170-glycoprotein efflux pump associated with multiple drug resistant cancer cells. Nonactin is a polyketide, albeit a highly atypical one.

中文名:无活菌素,英文名:Nonactin,CAS:6833-84-7,Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells. Nonactin, a natural mixture of macrotetrolides, was used …

中文名:无活菌素,英文名:Nonactin,CAS:6833-84-7,Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells. Nonactin, a natural mixture of macrotetrolides, was used …

2009年2月2日 · Nonactin, produced by Streptomyces griseus ETH A7796, is a macrotetrolide assembled from nonactic acid. It is an effective inhibitor of drug efflux in multidrug resistant erythroleukemia K562 cells at sub-toxic concentrations and has been shown to possess both antibacterial and antitumor activity.