2019年10月19日 · • The R1 side chain is the major factor for cross-reactivity due to antibody recognition between cephalosporins and penicillins. • Cross-reactivity with cefazolin or carbapenems is very unlikely • Cross-reactivity with monobactam (aztreonam) is absent, with the exception of ceftazidime

The NM -lactam cross-reactivity side chain chart is a guide and should be used with the NM -lactam Allergy Risk Assessment and Clinical Pathway for Outpatients or Non-Critically Ill Inpatients when assessing the decision to drug challenge with a -lactam.

The cross reactivity between penicillin and cephalosporins occurs in about 2% of cases. Prior rates of 8-10% were an over estimation of the degree of cross-reactivity between beta-lactams due to 1) cephalosporins contaminated with benzylpenicillin, 2) inclusion of in-vitro and retrospective studies not supported by skin testing, and 3 ...

Identities or similarities of β-lactam side-chain structures are mainly responsible for cross-reactivity among these antibiotics. For example, in aminopenicillin-allergic subjects, cross-reactivity with aminocephalosporins could possibly be over 30%.

We describe the impact of the cross-reactivity chart in combination with enhanced allergy assessment, antimicrobial stewardship, and pharmacy processes to optimize β-lactam use for patients with pneumonia and surgical prophylaxis.

This chart describes the risk of cross-reactivity between 2 beta-lactams antibiotics. Shaded boxes indicate either a similar (gray) or an identical (red) side chain, and therefore higher risk for an allergic reaction.

We describe a cohort of nine patients with non-SJS/TEN SCAR in which we found evidence of cross-reactivity in 75% in which the patterns of cross-reactivity seen were not predictable based on reactivity to the beta-lactam ring or the R1 side chain.

c = There is little potential for cross-reactivity between penicillin / cephalosporins and carbapenems; however, monitor closely if previous anaphylactic reaction to penicillins or cephalosporins X = Potential for cross-sensitivity Blank = Not cross-sensitive

2021年1月18日 · Identities or similarities of β-lactam side-chain structures are mainly responsible for cross-reactivity among these antibiotics. For example, in aminopenicillin-allergic subjects, cross-reactivity with aminocephalosporins could possibly be over 30%.

2021年4月26日 · Implementation of an antibiotic cross-reactivity chart combined with enhanced allergy assessment processes significantly improved the prescribing of β-lactam antibiotics for surgical prophylaxis.