NOTCH1 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus.

Notch1 (D1E11) XP ® Rabbit mAb detects intracellular epitopes between 2400 and 2500 amino acids of human Notch1. It recognizes both the full-length (~300 KDa) and the NTM region (~120 KDa), which consists of a short extracellular juxtamembrane peptide, a transmembrane sequence and the intracellular domain (NICD).

2013年10月27日 · The median survival time of Notch-1-positive or negative patients was 64.6 months (95% CI: 31.497-97.703 months) or 36.0 months (95% CI: 12.132-59.868 months). Notch-1 could be used as a predictable biomarker to be detected in different pathological and histological subtypes in LAD for diagnosis or prognosis.

Cleaved-Notch 1 (Val1744) Antibody detects endogenous levels of fragment of activated Notch 1 resulting from cleavage adjacent to Val1744.

2024年12月25日 · NOTCH1 (Notch Receptor 1) is a Protein Coding gene. Diseases associated with NOTCH1 include Aortic Valve Disease 1 and Adams-Oliver Syndrome 5. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Pre-NOTCH Expression and Processing.

NOTCH1 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus.

In present study, bioinformatics was utilized to study the expression of NOTCH1 gene in breast cancer from public databases, including the Kaplan-Meier Plotter, PrognoScan, Human P... ... Human...

Cleaved-Notch 1 (Val1744) Antibody detects endogenous levels of fragment of activated Notch 1 resulting from cleavage adjacent to Val1744. PBS,pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

2021年4月20日 · Notch 1 Antibody (A-8) is a mouse monoclonal IgM kappa light chain antibody specifically engineered to detect Notch1, also known as Neurogenic locus notch homolog protein 1, in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections ...

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

Find the NOTCH1 antibody that fits your needs. Choose from 1 of 54 NOTCH1 antibodies, which have been validated in experiments with 176 publications and 187 images featured in our data gallery. Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications.

Bethyl Laboratories Anti-Notch1 Polyclonal, Catalog # IHC-00538. Tested in Immunohistochemistry (IHC) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody reacts with Human samples. Supplied as 100 µL purified antibody (0.25 mg/mL).

Notch 1抗体（A-8）是一种IgM κ小鼠单克隆Notch 1抗体（也称为NOTCH1抗体），可通过WB、IP、IF、IHC（P）和ELISA检测小鼠、大鼠和人源的Notch 1蛋白。 Notch 1抗体（A-8）可作为非偶联抗Notch 1抗体形式以及多种偶联形式的抗Notch 1抗体，包括琼脂糖、HRP、PE、FITC和多 …

In the present study, we describe IHC analysis of Jagged-1 and Notch-1 proteins in human PCa and demonstrate elevated expression of Jagged-1 and Notch-1 in high grade and metastatic PCas, but not in low-grade PCas or HGPIN lesions.

We investigated whether the nonsentinel lymph node (NSLN) status in patients with melanoma improves the prognostic accuracy of common staging features; then we formulated a proposal for including...

2018年2月6日 · In this study, we validated that Notch1 and NF-κB (p65) are highly expressed in the classical and proneural subtypes of GBM using the data set from The Cancer Genome Atlas (TCGA) and the Chinese...

2013年6月18日 · Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been lacking. Here, we bridge this gap by developing an immunohistochemical (IHC) stain …

notch 1. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

IHC of Notch markers is feasible and correlates with known prognostic factors consistent with a biological role of Notch signaling in breast cancer progression.

2013年6月18日 · These findings indicate that NOTCH1 activation among B cell tumors is both more sharply restricted to and more prevalent in CLL than would be predicted from prior genotypic data, raise questions about the proposed tumor suppressive role for NOTCH1 in vascular neoplasms, and suggest that IHC testing for NICD1 can be used to select patients for ...