Neurogenic locus notch homolog protein 2 (Notch 2) is a protein that in humans is encoded by the NOTCH2 gene. [5] NOTCH2 is associated with Alagille syndrome [6] and Hajdu–Cheney …

2024年12月25日 · NOTCH2 (Notch Receptor 2) is a Protein Coding gene. Diseases associated with NOTCH2 include Alagille Syndrome 2 and Hajdu-Cheney Syndrome. Among its related …

The NOTCH2 gene provides instructions for making a protein called Notch2, a member of the Notch family of receptors. Receptor proteins have specific sites into which certain other …

研究发现， EB病毒 可以产生一种名为EB核抗原2（EBNA2）的蛋白质，该蛋白质可以模拟胞内域（intracellular Notch，ICN），进入细胞核，在相关辅助因子的参与下，与CSL蛋白相结合并使 …

Notch 信号通路是一条在进化中高度保守的，决定细胞命运的重要信号通路之一。 1. 别具一格的 Notch. 大多经典的信号通路 (如 RTK 信号通路) 遵循“信号-受体-信号转导 (产生二次信使)-细胞 …

2024年12月25日 · NOTCH2NLC (Notch 2 N-Terminal Like C) is a Protein Coding gene. Diseases associated with NOTCH2NLC include Neuronal Intranuclear Inclusion Disease and …

Notch-2 was identified as a novel target for beta-catenin-dependent Wnt signaling. This study demonstrated a close correlation of Notch2 expression with gastric cancer formation and the …

Notch is a ligand-activated single pass transmembrane receptor that acts as a membrane-tethered transcription factor. Cleavage of the notch intracellular domain (NICD) requires …

2025年3月6日 · The NOTCH2 gene encodes a single pass transmembrane protein belonging to an evolutionarily conserved NOTCH receptor family (see, e.g., NOTCH1; 190198).

In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch …