This gene encodes the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a …

Dx promotes ligand-independent activation of Notch following removal of ECD by an Adam10-independent mechanism and presenilin-dependent release of intracellular domain (ICD) through S3 cleavage.

Activation of Notch takes place primarily in "connector" cells and cells that line patent stable blood vessels through direct interaction with the Notch ligand, Delta-like ligand 4 (Dll4), which is expressed in the endothelial tip cells. [108]

2022年3月24日 · NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes. NOTCH signaling deeply participates in the development and homeostasis of...

2023年4月10日 · Delta样配体-3（δ-like ligand 3） 是一种单程 I 型跨膜蛋白，属于抑制性Notch通路配体家族成员之一， Notch信号通路 是一种高度保守的细胞间信号通路，参与多种发育过程，包括肺神经内分泌细胞的发育1-2，而DLL3在Notch信号传导中发挥关键作用。

Ligand-dependent clustering of Notch has been proposed to allow trans-regulatory complexes to withstand the mechanical pulling force generated by ligand endocytosis during the activation process suggesting that avidity effects may contribute to the mechanism of activation [41].

2008年9月1日 · The current model of canonical Notch signaling suggests that it is triggered when the specific ligand on one cell interacts with the extracellular domain of a Notch receptor on a neighboring...

2024年12月25日 · This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development.

2010年1月13日 · In screening a library of 155 peptides representing all 34 EGF-like repeats in Notch3, we discovered two distinct ligand-binding regions involving the 7–10 and 21–22 repeats that are distinct from the putative ligand-binding domain of Notch1.

The Notch signaling pathway is an evolutionarily conserved intercellular signaling cascade that regulates a number of cellular processes, including cell development, proliferation, apoptosis, and genome stability. The Notch signaling pathway is ...