2024年5月27日 · Accumulating evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer types. Dysregulation of …

2022年3月24日 · In terms of cancers, NOTCH signaling can both promote and inhibit tumor development in various types of cancer. The overall performance of NOTCH-targeted …

Aberrant expression or mutation of Notch has been linked to the onset and progression of a variety of malignant tumors. In this review, we discussed the mechanism of Notch signaling in …

2020年12月8日 · Notch signalling is involved in many aspects of cancer biology, including angiogenesis, tumour immunity and the maintenance of cancer stem-like cells. In addition, …

2017年1月24日 · Here, after briefly reviewing new insights into physiologic mechanisms of Notch signaling in healthy tissues and defects in Notch signaling that contribute to congenital …

2024年5月27日 · The regulatory role of the Notch signaling pathway in cancer metabolic reprogramming and the tumor microenvironment suggests its pivotal involvement in balancing …

2022年10月1日 · This review provides an overview of the roles of Notch in cancer and discusses challenges to clinical translation of Notch targeting agents as well as approaches that may …

2023年5月2日 · The Notch signaling pathway, which is highly conserved across species, is implicated in numerous aspects of cancer biology, including the cancer stem cell phenotype, …

2015年12月1日 · The Notch signaling pathway is commonly activated in cancer and its activation plays key role in the progress of cancer. Pharmacological inhibitors of this pathway can …

Notch is a key evolutionary conserved pathway, which has fascinated and engaged the work of investigators in an uncountable number of biological fields, from development of metazoans to …