Neurogenic locus notch homolog protein 3 (Notch 3) is a protein that in humans is encoded by the NOTCH3 gene. [5][6] This gene encodes the third discovered human homologue of the …

2024年12月25日 · NOTCH3 (Notch Receptor 3) is a Protein Coding gene. Diseases associated with NOTCH3 include Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts …

2023年12月20日 · 摘要： Notch3 是四种哺乳动物 Notch 蛋白之一，它充当信号受体，在许多发育和成体组织环境中控制细胞命运。 Notch 信号传导在成人有机体中对于组织维持和更新仍然很 …

The NOTCH3 gene provides instructions for making a protein with one end (the intracellular end) that remains inside the cell, a middle (transmembrane) section that spans the cell membrane, …

Notch信号传导通路发挥致癌作用，导致细胞在增殖，细胞周期抑制，分化，和凋亡的过程失调和失控，造成了细胞的转化及恶性化，最终导致了恶性肿瘤的发生。

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control cell fate in many developmental and adult tissue contexts. Notch signalling continues to be …

2022年3月24日 · NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes. NOTCH signaling deeply participates in the …

Delta-like ligand 3 (DLL3) 是一种抑制性Notch配体，在小细胞肺癌（SCLC）和其他神经内分泌肿瘤中高表达，而在正常组织中最低表达。 因而DLL3作为SCLC中的潜在治疗靶受到安进、艾 …

The NOTCH3 gene encodes a single pass transmembrane protein belonging to an evolutionarily conserved NOTCH receptor family (see, e.g., NOTCH1; 190198). After ligand binding, the …

It is well established that NOTCH3 gene on chromosome 19 is primarily responsible for the development of the CADASIL syndrome. Herein, an attempt is made to shed light on the …