Neurogenic locus notch homolog 4 (Notch 4) is a protein that in humans is encoded by the NOTCH4 gene located on chromosome 6. [5] An alternative splice variant of the NOTCH4 gene has been described, but its biological significance has not been determined. [6] The neurogenic locus notch homolog 4 protein is a member of the Notch family.

2024年12月25日 · NOTCH4 (Notch Receptor 4) is a Protein Coding gene. Diseases associated with NOTCH4 include Schizoaffective Disorder and Schizophrenia. Among its related pathways are Pre-NOTCH Expression and Processing and Regulation of activated PAK-2p34 by proteasome mediated degradation.

Notch受体是由Notch基因编码的单跨膜蛋白，在包括人类在内的哺乳动物中发现了 4种Notch受体（Notch 1，2，3，4）。 而Notch配体也是表达于细胞表面的单跨膜蛋白，相邻细胞通过Notch受体和配体的结合，传递Notch信号。 人体有 5种Notch配体，分别是Jagged 1、Jagged 2、Delta 1、Delta 3和Delta 4。 Notch配体与受体结合后触发Notch信号的活化，Notch受体相继发生2次蛋白水解，并进一步转移到细胞核，从而激活靶基因的转录，发挥生物学功能。 Notch信号调节 …

Notch蛋白 （在脊椎动物中为Notch1-Notch4）是一种单通路受体，它们通过与 Delta （或Delta-like）和Jagged/Serrate家族的膜结合配体相互作用而被激活。 它们以被切割但否则完整的多肽形式运输到质膜上。 与配体的相互作用引起两个额外的蛋白酶解剖，从而将Notch细胞膜内区域（NICD）从质膜中释放出来。 NICD转移到细胞核，在那里它与DNA结合蛋白 CSL 形成复合物，将组蛋白去乙酰化酶（HDAc）共抑制剂（CoR）复合物从CSL中移走。 激活复合物的组 …

2022年3月24日 · NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes. NOTCH signaling deeply participates in the development and...

2023年3月26日 · Notch 信号是造血、免疫细胞分化的关键调节因子之一，与多种自身免疫性疾病、肿瘤的发生和肿瘤诱导的免疫抑制有关。 Notch 信号通路本身简单，但它所调控的细胞进程却相当复杂。 2022年3月24日，华中科技大学附属同济医院肿瘤科褚倩教授为通讯作者，在顶尖期刊《Signal Transduction and Targeted Therapy》（IF值为 38.104 分）上发表题为“Notch signaling pathway: architecture, disease, and therapeutics”的综述性文章，详细阐述了 Notch 信号的研 …

2014年7月1日 · Notch4 is a divergent member of the Notch family of receptors that is primarily expressed in the vasculature. Its expression implies an important role for Notch4 in the vasculature; however, mice homozygous for the Notch4d1 knockout allele are viable.

2021年6月8日 · In a prospective multi-country cohort of COVID-19 patients, we found that increased Notch4 expression on circulating regulatory T (Treg) cells was associated with disease severity, predicted mortality, and declined upon rec …

其中，首次揭示NOTCH4作为转录因子RUNX1的直接靶基因，负向调控体外巨核细胞发育；并筛选出Notch通路的小分子抑制剂，使得从多能干细胞和脐血来源的造血干祖细胞，生成巨核细胞的产量提高近十倍。

Gene target information for NOTCH4 - notch receptor 4 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.