Notch1, a member of the Notch family, is implicated in many types of cancer, including breast cancer (especially triple-negative breast cancer), leukemias, brain tumors, and many others. Notch1 is tightly connected to many signaling pathways that are therapeutically involved in …

We demonstrate a novel interaction of the nephroblastoma overexpressed gene (NOV), a member of the CCN gene family, with the Notch signaling pathway. NOV associates with the epidermal growth factor-like repeats of Notch1 by the CT (C-terminal cysteine knot) domain.

The NOTCH1 gene provides instructions for making a protein called Notch1, a member of the Notch family of receptors. Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks.

2024年12月25日 · NOTCH1 (Notch Receptor 1) is a Protein Coding gene. Diseases associated with NOTCH1 include Aortic Valve Disease 1 and Adams-Oliver Syndrome 5 . Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Pre-NOTCH Expression and Processing .

2002年8月16日 · We demonstrate a novel interaction of the nephroblastoma overexpressed gene (NOV), a member of the CCN gene family, with the Notch signaling pathway. NOV associates with the epidermal growth factor-like repeats of Notch1 by the CT (C-terminal cysteine knot) domain.

作者团队通过不同实验方法验证了神经胶质瘤起始细胞 (GICs) 中完整的 Notch1-CXCR4-PI3K 信号通路，证明了 Notch1 通过调节趋化因子系统 CXCL12/CXCR4，促进胶质瘤起始细胞的侵袭、自我更新和生长。 图 3. Li Yi 等人验证 Notch 与 CXCR4 相关通路的实验思路图. 该团队首先通过磁珠分选 (MACS) 的方法，富集 U87 和 U251 胶质瘤细胞的 CD133+ (肿瘤起始细胞标记物) 细胞。 CD133+ 胶质瘤细胞球中表现出高的 Notch1 活性 (图 4a，橘红色荧光)。

2002年9月1日 · We demonstrate a novel interaction of the nephroblastoma overexpressed gene (NOV), a member of the CCN gene family, with the Notch signaling pathway. NOV associates with the epidermal growth...

We demonstrate a novel interaction of the nephroblas-toma overexpressed gene (NOV), a member of the CCN gene family, with the Notch signaling pathway. NOV associates with the epidermal growth factor-like re-peats of Notch1 by the CT (C-terminal cysteine knot) domain.

5 天之前 · The Notch pathway regulates many developmental and homeostatic processes in animals. This Review discusses how different modes of Notch signalling can have different functional outcomes, and how ...

2007年7月6日 · Although Notch inhibits osteoblastic differentiation, Nov overexpression did not increase but inhibited the transactivation of a 12xCSL-Luc reporter construct and the transcription of HES-1. The reason why Nov opposes Notch signaling has not been elucidated, but similar results were reported in C2C12 myoblastic cells (69). The difference ...