2023年5月31日 · Recent studies have demonstrated that donation after circulatory death (DCD) may be noninferior to donation after brain death (DBD) in heart transplantation. 1 With the growing capability of ex-situ organ perfusion, DCD heart transplantation has the potential to expand the donor pool by 30% in the United States. 2 This new era raises new ...

2022年10月10日 · Heart transplantation (HT) using organ donation after circulatory death (DCD) has grown rapidly in the United States since 2019. DCD HTs represented >5% of all HTs performed in 2021 and is now performed at >15% of US HT centers.

2022年11月21日 · Machine perfusion enabled the success of DCD heart transplant by mitigating previous deleterious effects of warm ischemia. DCD and DBD heart transplant have similar outcomes. Widespread adoption of DCD heart transplant can expand the donor pool, resulting in increased transplant volume and decreased waitlist times.

2022年10月22日 · DCD programs are now emerging across Europe and the USA with early success. It is now established that the uptake of DCD donor hearts has the impact of improving overall heart transplantation numbers and can legitimately contribute to the reduction of global transplant wait lists.

2019年9月3日 · Donation after circulatory death (DCD) has become an accepted practice in many countries and remains a focus of intense interest in the transplant community. The present study is aimed at providing a description of the current situation of DCD in European countries.

2024年10月9日 · To summarise current international clinical outcomes from donation after circulatory death heart transplantation (DCD-HT); discuss procurement strategies, their impact on outcomes and overall organ procurement; and identify novel approaches and future areas for research in DCD-HT.

Donation after cardiac death (DCD) has been a begrudgingly acceptable process around the world. 2 For years now, DCD has provided viable livers, lungs, and kidneys. The clinical results have been reasonable and better than the alternative of discarding organs and death on the transplant waitlist.

2024年6月20日 · This review aims to present the current state and future trajectory of DCD-heart transplant, examine key differences between DCD and donation after brain death, including clinical experiences and innovations in methodologies, and address the ongoing ethical challenges surrounding the new frontier in heart transplant with DCD donors.

2021年4月7日 · Heart transplantation from donation after circulatory death (DCD) donors is a rapidly expanding practice. In this review, we describe the history and challenges of DCD heart transplantation and overview the procurement protocols and methods of limiting ischemic injury, current outcomes, and future directions.

Despite the belief of increased risk, DCD outcomes now have comparable safety and long-term efficacy. Future developments in machine perfusion and normothermic regional perfusion could even further improve outcomes and utilization.