2024年12月25日 · NOX1 (NADPH Oxidase 1) is a Protein Coding gene. Diseases associated with NOX1 include Visceral Myopathy 1 and Chronic Granulomatous Disease. Among its related pathways are Signaling by Rho GTPases and Alzheimer's disease and miRNA effects. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and …

NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene. [5] NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene. [6]

2021年6月1日 · NOX from phagocytes catalyzes, via one-electron trans-membrane transfer to molecular oxygen, the production of the superoxide anion. Over the years, six human homologs of the catalytic subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2.

2024年6月6日 · 人体细胞中，nox 家族蛋白包括7种亚型，其中 nox1～5 是六次跨膜蛋白，duox1 和 duox2 是七次跨膜蛋白。 NOX2 (通常也称作 gp91phox) 是首个发现的 NOX 家族蛋白。

该基因编码 NADPH 氧化酶的一个亚基，它是一种膜结合的多亚基蛋白。 这种复合物催化电子从 NADPH 转移到分子氧以产生超氧化物或过氧化氢，并可能在抗菌杀灭和细胞信号传导中发挥作用。 这种蛋白质结合其他亚基以产生超氧化物。 在小鼠中，这种酶的缺乏可能与血压变化有关。 [RefSeq 提供，2013 年 6 月] This gene encodes a subunit of the NADPH Oxidase enzyme, which is a membrane-bound, multisubunit protein.

NOX1 deficiency plus TNFα stimulation contribute to colitis through dysregulation of the stem cell niche and altered cell differentiation, enhancing basal lymphoplasmacytosis. Our findings prioritise ROS modulation for future therapies.

2022年5月18日 · Professional phagocytes such as neutrophils (PMNs), eosinophils, monocytes, and macrophages use superoxide-generating NADPH oxidase (NOX) as part of their arsenal of antimicrobial mechanisms to...

2025年1月4日 · 12-lipoxygenase pathway is upstream of Nox1 activation and controls cell spreading and proliferation, while Nox1 specifically affects cell proliferation. Nox1-based oxidase system may be a potential marker of neoplastic transformation and play an important role in oxygen radical- and inflammation-dependent carcinogenesis in the stomach.

2024年11月2日 · Title: Role of NOX1 and NOX5 in protein kinase C/reactive oxygen species‑mediated MMP‑9 activation and invasion in MCF‑7 breast cancer cells. NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease.

2019年1月30日 · We previously showed that NADPH oxidase organizer 1 (Noxo1), a component of NADPH oxidase 1 (NOX1), is a TNF-α-induced tumor-promoting factor in gastric tumorigenesis....