Nox4 protects the vasculature against inflammatory stress. [6] Nox-dependent reactive oxygen species modulation by amino endoperoxides can induce apoptosis in high Nox4-expressing cancer cells. [7] A study found that NOX4 facilitates certain beneficial adaptive responses to exercise mediated by ROS.

Nox4 is also induced by other stresses such as cardiac load-induced stress 67 and by inflammatory mediators via the NF-κB pathways 68 and in the former system has been shown to exert a beneficial effect, in contrast to the detrimental effect of Nox2 induction. 67 Thus, Nox4-derived H 2 O 2 may participate in signaling by both acute mechanisms ...

2010年8月31日 · Nox4 expression was inhibited in c-Nox4(-/-) mice in a heart-specific manner, and there was no compensatory up-regulation in other Nox enzymes. These mice exhibited reduced levels of O(2)(-) in the heart, indicating that Nox4 is a significant source of O(2)(-) in cardiac myocytes. The baseline cardiac phenotype was normal in young c-Nox4(-/-) mice.

2024年12月25日 · NOX4 (NADPH Oxidase 4) is a Protein Coding gene. Diseases associated with NOX4 include Ureteral Obstruction and Pulmonary Hypertension.Among its related pathways are FLT3 signaling in disease and Alzheimer's disease and miRNA effects.Gene Ontology (GO) annotations related to this gene include nucleotide binding and heme binding.An important …

Nox4, one of the seven members of Nox family (Nox1, Nox2, Nox3, Nox4, Nox5, Duox1 and Duox2), has been extensively investigated in recent years. Its unique structures result in the constitutive generation of hydrogen peroxide (H2O2) as the main product. As a key oxygen sensor, Nox4-derived H2O2 plays diverse roles in cell proliferation ...

2023年6月23日 · Nox4, originally termed “Renox”, was first identified in kidney cortex [1, 2] and nearly simultaneously in osteoclasts [] as a novel superoxide (O 2 •−)-generating oxidase.Since that time, much has been learned about its structure, binding partners, tissue and subcellular distribution, role in the biology of the cell and contributions to normal physiological and …

2017年10月19日 · NOX4 directly binds ATP through a Walker A binding motif. We examined the primary sequence of NOX4. Interestingly, we find that NOX4 harbors a putative, yet unexplored, Walker A, P-loop ATP/GTP ...

2014年8月12日 · Nox4 is an oddity among members of the Nox family of NADPH oxidases [seven isoenzymes that generate reactive oxygen species (ROS) from molecular oxygen] in that it is constitutively active. All other Nox enzymes except for Nox4 require upstream activators, either calcium or organizer/activator subun …

Nox4, an oxidase linked to cardiovascular disease, carcinogenesis, and pulmonary fibrosis, deviates from this model by displaying constitutive H 2 O 2 production without requiring known regulators. Extensive Nox4/Nox2 chimera screening was initiated to pinpoint structural motifs essential for ROS generation and Nox subcellular localization.

2025年2月8日 · Nox4 is a major superoxide-producing enzyme and its expression is regulated by Ang II and hypoxic stress in human brain pericytes. Nox4 NADPH oxidase may be an important downstream effector in mediating TGF-beta-induced fibrosis, while NADPH oxidase-dependent redox signaling may in turn regulate TGF-beta/Smad signaling in a feed-forward manner.