The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior.

2024年12月25日 · NPAS4 (Neuronal PAS Domain Protein 4) is a Protein Coding gene. Diseases associated with NPAS4 include Autism Spectrum Disorder and Inflammatory Bowel Disease 14. Among its related pathways are Transcriptional Regulation by NPAS4 and …

2023年2月15日 · By characterizing the landscape of activity-induced DNA double-strand breaks in the brain, we show that NPAS4–NuA4 binds to recurrently damaged regulatory elements and recruits additional DNA...

这种经历与神经元PAS结构域蛋白4（Npas4）的表达有关，Npas4是一种公认的其他神经元基因的调节剂。 在这期的1282页，秋木等报告了Npas4表达式的分子细节是如何受控的，它包括编码和非编码Npas4 RNA、RNA-DNA杂交形成，以及基因座内的三维（3D）染色质环。

Neuronal PAS domain protein 4 (Npas4) is a recently discovered calcium-dependent transcription factor that regulates the activation of genes involved in the homeostatic regulation of excitatory–inhibitory balance, which is critical for neural circuit formation, function, and ongoing plasticity, as well as for defense against diseases such as epi...

2021年10月20日 · Our data indicate that NPAS4 is necessary for normal transcriptional responses to light in the SCN and critical for photic phase-shifting of circadian behavior. Keywords: NPAS4; light simulation; single-nucleus RNA sequencing; suprachiasmatic nucleus.

2014年5月22日 · Npas4 is an early-response transcription factor that is enriched in the brain and induced in excitatory neurons specifically upon calcium influx and that has been suggested to regulate excitatory-inhibitory balance within neural circuits (Bloodgood et …

2013年11月6日 · The transcription factor NPAS4 enables neurons to distinguish synaptic inputs received at their soma or dendrites; sensory stimulation increases NPAS4 which promotes...

2021年10月20日 · Our data indicate that NPAS4 is necessary for normal transcriptional responses to light in the SCN and critical for photic phase-shifting of circadian behavior.

2016年3月14日 · Npas4 is involved in activity-dependent synaptic modulation in both excitatory and inhibitory neurons. It regulates the expression of a large number of activity-regulated genes that mediate diverse effects on synapses. Npas4 function is required for memory formation in multiple brain regions.