2020年10月8日 · NPM1 mutations represent the most common genetic lesion in adult acute myeloid leukemia (AML; about one third of cases), and they act deterministically to cause the …

2021年2月4日 · Acute myeloid leukemia (AML) carrying mutations of nucleophosmin (NPM1), a gene encoding for a multifunctional nucleolar protein with chaperone and shuttling features, 1 …

2023年11月11日 · NPM1突变AML是成人 AML 中最大的分子学亚组（30-35%），可通过分子技术和免疫组化进行识别，两者联合使用时可解决困难的诊断问题（包括识别髓系肉瘤和外显子12 …

The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal …

The nucleophosmin 1 (NPM1) gene is mutated in approximately one-third of newly diagnosed acute myeloid leukemia (AML) cases. NPM1mutated AML (NPM1mut-AML) has been …

Somatic mutations in exon 12 of the NPM gene (NPM1) are the most frequent genetic abnormality in adult AML, found in approximately 35% of all cases and up to 60% of patients with normal …

2024年1月8日 · NPM1-mutated acute myeloid leukemia (AML) represents the largest molecular subgroup of adult AML. NPM1-mutated AML is recognizable by molecular techniques and …

2021年2月4日 · Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional protein, occur in approximately one-third of adult acute myeloid leukemia …

急性髓系白血病（aml），是成人中较为常见的一种急性白血病，也是最具侵袭性和最难治疗的血液癌症之一。 该病多发于中老年群体，男性发病率高于女性，患者五年生存率约为 28%。

2023年1月16日 · NPM1mutated AML (NPM1 mut-AML) has been reclassified as a distinct entity in the 2022 World Health Organization (WHO 2022) and European Leukemia Network (ELN …