2019年7月18日 · In this study, we focused on translationally controlled tumor protein (TCTP), a highly conserved protein that is expressed ubiquitously in mammalian tissues, including...

2021年10月21日 · Here, we investigated the role of mTORC1 in regulating TCTP protein levels, thereby modulating chemosensitivity, in human lung cancer cells and an A549 lung cancer xenograft model. The inhibition...

2022年4月19日 · Here, using the transcriptome data of patients, and immune-refractory tumor models, we identify TCTP as an immune-resistance factor that correlates with clinical outcome of anti-PD-L1 therapy and...

2022年10月27日 · Translationally controlled tumor protein (TCTP) is a multifunctional protein that plays a wide variety of physiological and pathological roles, including as a cytoplasmic repressor of Na,K-ATPase, an enzyme pivotal in maintaining Na + and K + ion gradients across the plasma membrane, by binding to and inhibiting Na,K-ATPase.

2008年12月5日 · TCTP acts as the guanine nucleotide exchange factor of the Ras GTPase Rheb that controls TOR activity in Drosophila melanogaster. We therefore examined the role of Arabidopsis thaliana TCTP in planta. Plant TCTPs exhibit distinct sequence differences from nonplant homologs but share the key GTPase binding surface.

2017年11月18日 · The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes.

2020年5月6日 · Translationally controlled tumor protein (TCTP) is a conserved, multifunctional protein involved in numerous cellular processes in eukaryotes. Although the functions of TCTP have been investigated sporadically in animals, invertebrates, and plants, few lineage-specific activities of this molecule, have been reported.

By employing Drosophila genetics, we demonstrate that TCTP plays a crucial role in regeneration of damaged intestinal epithelium in part by regulating protein translation. Furthermore, we elucidate an unexpected crosstalk between TCTP and 2 …

2018年1月1日 · To investigate the role of TCTP in EMT, the present study focuses on the association of TCTP with growth factor-induced EMT and cytoskeleton modulation. Here we propose a model illustrating the increased expression of TCTP during TGF-β1 and epithelial growth factor (EGF)-induced EMT in cancer cell lines and its effect in cytoskeleton ...

2021年7月8日 · Here, we show that translationally controlled tumor protein (TCTP) released by dying tumor cells is an immunomodulator crucial to full-blown MDSC accumulation in the TIME. We provide evidence...