Regulatory Landscapes of Nppa and Nppb | Circulation Research
2021年1月7日 · Nppa encodes ANP (atrial natriuretic peptide), whereas Nppb encodes BNP (B-type natriuretic peptide), both hormones secreted by the heart and involved in cardiac …
中国药科大学联合阜外医院研究团队共同发表IF: 29.983高水平文章 …
这些结果表明了在压力过载的刺激下NEU1会进入细胞核，入核后选择性结合GATA4，促进GATA4与心肌肥厚相关基因Nppa（ANP）、Nppb（BNP）启动子的结合，并激活它们的表 …
Structure and function of the Nppa–Nppb cluster locus during …
In this review, we will provide recent insights into the dynamic and complex regulation of Nppa and Nppb during heart development and hypertrophy, and the association of this gene cluster …
Structure and function of the Nppa-Nppb cluster locus during …
In this review, we will provide recent insights into the dynamic and complex regulation of Nppa and Nppb during heart development and hypertrophy, and the association of this gene cluster …
Cardiac natriuretic peptides | Nature Reviews Cardiology
2020年5月22日 · Translation of NPPA and NPPB gives rise to preprohormones (preproANP and preproBNP, respectively) that are further processed to prohormones (proANP and proBNP) …
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb ...
2020年10月27日 · ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide), encoded by the clustered genes Nppa and Nppb, are important prognostic, diagnostic, and therapeutic …
<br>Nppa-Nppb 簇基因座在心脏发育和疾病过程中的结构和功能 …
这两种利钠肽激素由进化保守的旁系同源基因 Nppa 和 Nppb 编码。 这两种基因在胚胎和胎儿阶段主要由心肌表达，特别是 Nppa 表达在出生后在心室中强烈减少。
在心脏发育和压力过程中控制Nppa-Nppb基因簇的调节域的鉴定 …
2016年4月7日 · Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress. The paralogous genes Nppa and Nppb are organized in …
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb ...
2021年1月8日 · Coordinated ventricular expression of <i>Nppa</i> and <i>Nppb</i> is controlled in a competitive manner by a shared super enhancer, which is also required to augment stress …
利钠肽 B（NPPB）基因 | MCE
心肌损伤的存在是 2019 年冠状病毒病 (COVID-19) 住院患者死亡率的重要预测因素，并且有证据表明住院非幸存者 COVID-19 患者的利钠肽 B 水平升高。 该蛋白质还充当具有抗菌和抗真菌 …
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