2024年12月25日 · NR0B2 (Nuclear Receptor Subfamily 0 Group B Member 2) is a Protein Coding gene. Diseases associated with NR0B2 include Body Mass Index Quantitative Trait Locus 11 and Hemopneumothorax. Among its related pathways are Gene expression (Transcription) and Nuclear receptors.

The small heterodimer partner (SHP) also known as NR0B2 (nuclear receptor subfamily 0, group B, member 2) is a protein that in humans is encoded by the NR0B2 gene. [5] SHP is a member of the nuclear receptor family of intracellular transcription factors. [6] SHP is unusual for a nuclear receptor in that it lacks a DNA binding domain.

2024年9月16日 · Small Heterodimer Partner (SHP; NR0B2) is an orphan receptor that acts as a transcriptional regulator, controlling various metabolic processes, and is a potential therapeutic target for cancer. Examining the correlation between the expression of NR0B2 and the risk of gastric diseases could open a new path for treatment and drug development.

The orphan nuclear receptor NR0B2 could be a novel susceptibility locus associated with microsatellite-stable, APC mutation-negative early-onset colorectal carcinomas with metabolic manifestation. The long and the small collide: LncRNAs and small heterodimer partner (SHP) in …

该基因产物是核激素受体家族的成员，核激素受体家族是一组受小疏水激素调节的转录因子，其中一部分没有已知的配体，被称为孤儿核受体。 该蛋白质已被证明与类视黄醇和甲状腺激素受体相互作用，抑制其配体依赖性转录激活。 此外，已证明与雌激素受体的相互作用会导致功能抑制。 研究表明，该蛋白质通过两个独立的步骤抑制核激素受体介导的反式激活：与共激活因子的竞争及其转录抑制功能的直接影响。 [RefSeq 提供，2008 年 7 月]

2009年10月29日 · NR0B2 is an orphan member of the nuclear receptor superfamily that contains the dimerization and ligand-binding domains found in other family members, but lacks the conserved DNA-binding domain. NR0B2 heterodimerizes with other nuclear receptor superfamily members and inhibits transactivation by these receptors ( Seol et al., 1996 ).

Interacts with DDX3X; this interaction disrupts the interaction between HNF4 and NR0B2/SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers (PubMed: 28128295). Search… Showing features for domain. Belongs to the nuclear hormone receptor family. NR0 subfamily. Search… No translation available.

2017年1月4日 · The nuclear receptor small heterodimer partner (SHP, Nr0b2) was originally identified in 1996 as a transcriptional repressor based on its protein-protein interactions with several nuclear receptor superfamily members such as retinoid receptors, the thyroid hormone receptor, and the orphan receptor MB67 (Seol et al. 1996). The SHP gene consists ...

2021年5月13日 · NR0B2 (nuclear receptor subfamily 0 group B member 2), also called small heterodimer partner (SHP), is an orphan nuclear receptor without a conventional zinc-finger DNA binding domain (7).

2016年11月17日 · The orphan nuclear receptor NR0B2 could be a novel susceptibility locus associated with microsatellite-stable, APC mutation-negative early-onset colorectal carcinomas with metabolic manifestation. Lam KK, Sethi R, Tan G, Tomar S, Lo M, Loi C, Tang CL, Tan E, Lai PS, Cheah PYLam KK, et al .