2024年12月25日 · NR5A2 (Nuclear Receptor Subfamily 5 Group A Member 2) is a Protein Coding gene. Diseases associated with NR5A2 include Hepatitis B and Hepatitis. Among its related pathways are Gene expression (Transcription) and ESR-mediated signaling.

2023年11月7日 · We found that NR5A2, an NR TF strongly induced upon ZGA, was required for this connection. Upon Nr5a2 knockdown or knockout, embryos developed beyond 2C normally with the zygotic genome largely...

2023年11月15日 · nr5a2在早期胚胎发育中连接基因组激活与第一次细胞命运决定. nr5a2是一个核受体家族转录因子。颉伟课题组前期研究表明发现nr5a2在zga过程中被激活，并且其dna结合基序也在2-8细胞时期胚胎开放染色质中呈现明显富集。

In vitro studies on mouse embryos have recently identified the orphan nuclear receptor NR5A2 as a key player at this developmental stage. However, although NR5A2 was initially considered essential for ZGA, it was subsequently shown that this TF exerts its main function later, during morula formation.

2024年2月26日 · Nr5a2 is a key pioneer factor that regulates zygotic genome activation in totipotent embryos, pluripotency in embryonic stem cells and metabolism in adult tissues, but the mechanism of its...

2022年12月7日 · 为了揭开哺乳动物中合子基因组激活的关键调控因子，德国马克斯普朗克生化研究所Kikuë Tachibana研究组在Science发表了题为Zygotic genome activation by the totipotency pioneer factor Nr5a2的研究论文，发现 孤儿核受体Nr5a2 会作为先锋因子（Pioneer factor）激活小鼠胚胎全基因组的 ...

2022年11月24日 · We found that Nr5a2 binds near transcription start sites of Nr5a2-regulated ZGA genes and that binding positively correlates with the expression of target genes during ZGA. Nr5a2 preferentially targets cell type–specific putative enhancers in two-cell embryos versus embryonic stem cells, which suggests that Nr5a2 distinctly regulates ...

2016年7月22日 · Overexpression and loss-of-function experiments in primary NSCs and mouse embryos suggest that NR5A2 synchronizes cell-cycle exit with induction of neurogenesis and inhibition of astrogliogenesis...

2024年10月4日 · Using mouse models of the TF Nr5a2, we show that Nr5a2-/-embryos arrest at the early morula stage and exhibit altered lineage specification, frequent mitotic failure, and substantial chromosome segregation defects. Although NR5A2 plays a minor but measurable role during zygotic genome activation, it predominantly acts as a master regulator at ...

2024年3月26日 · Recent studies have elucidated Nr5a2’s role in activating zygotic genes during early mouse embryonic development. Subsequent research, however, reveals that Nr5a2 is not critical for zygotic genome activation but is vital for the gene program between the 4- …