2012年7月19日 · NFE2-related factor 2 (NRF2) has apparently contradictory roles in cancer. Activation of NRF2 contributes to the chemopreventive effects of various clinically used drugs …

2024年9月27日 · We demonstrated that NRF2 facilitates tumor proliferation, migration, and invasion, as evidenced by both in vitro and in vivo studies. Significantly, NRF2 augments the …

In breast cancer, Nrf2 activation leads to the overexpression of Rho and the downstream proteins FAK (focal adhesion kinase 1), MLC (modulator of volume-regulated anion channel current 1), …

2018年7月9日 · Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic …

Here in this research, we systematically review the function and role of Nrf2 signaling pathway in several typical malignant tumors, summarize the recent progress of Nrf2 in cancer treatment …

2022年6月30日 · Transient Nrf2 activation, by its specific activators, has protective roles against carcinogenesis and cancer development. However, permanent activation of Nrf2 promotes …

2018年5月3日 · Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic …

The constitutive activation of Nrf2 in various cancers induces pro-survival genes and promotes cancer cell proliferation by metabolic reprogramming, repression of cancer cell apoptosis, and …

2018年7月9日 · In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects. The transcription factor nuclear factor …

Just as NRF2 can protect normal cells from damage, it can protect malignant cells from damage. As cells transform, they are exposed to many stressors and aberrant upregulation of NRF2 …