
靶点解惑Plus | NF-κB p65, p62和 Nrf2信号通路详解,剖析氧化应 …
NF-κB p65 是NF-κB家族成员之一,NF-κB是一种多效性转录因子,几乎存在于所有细胞类型中,并参与许多生物学过程,例如炎症、免疫、分化、细胞生长、肿瘤发生和凋亡。 NF-κB受翻译后修饰和亚细胞区室化的各种机制以及与其他辅因子或共抑制因子的相互作用的控制。 p65-RelA是哺乳动物NF-κB家族的成员,该家族由5个亚基组成:p50-NF-κB1,p52-NF-κB2,c-Rel,p65-RelA和RelB。
Nuclear factor p65 interacts with Keap1 to repress the Nrf2 ... - PubMed
Knock down of Keap1 by RNA interference partially blocked the repression of Nrf2-mediated activation by p65. It was demonstrated that p65 decreased Nrf2 binding to its cognate DNA sequences and enhanced Nrf2 ubiquitination. The N-terminal region of p65 is necessary for both the interaction with Keap1 and its transcriptional suppression activity.
Transcription factors NRF2 and NF-κB are coordinated ... - PubMed
2014年5月30日 · In contrast, NRF2-deficient cells showed increased p65-NF-κB protein levels, although the mRNA levels remain unchanged, indicating post-translational alterations. Our results demonstrate a new mechanism of modulation of RAC1 inflammatory pathway through a cross-talk between NF-κB and NRF2.
Nature Communications丨Nrf2 通过阻止促炎细胞因子的转录来抑 …
这些结果表明,Nrf2 通过干扰 p65 介导的基因转录激活来抑制 IL6 基因的表达。 鉴于炎症反应转录因子与 Nrf2 结合区非常接近(图 6a,c),Nrf2 可能会干扰这些转录因子(如 p65)和/或炎症诱导转录所需的辅助因子的功能。
NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 …
2008年5月1日 · Here, we report that NF-κB p65 subunit repressed the Nrf2-antioxidant response element (ARE) pathway at transcriptional level. In the cells where NF-κB and Nrf2 were simultaneously activated, p65 unidirectionally antagonized the transcriptional activity of Nrf2.
NF-kB信号通路与炎症 - 知乎 - 知乎专栏
2023年3月30日 · 免疫荧光染色p-p65在核内荧光强度变化。 NF-kB通路常用抑制剂: BAY 11-7082 (MCE) 为IκBα 磷酸化和 NF-κB 抑制剂,选择性且不可逆地抑制 TNF-α 诱导的 IκB-α 磷酸化,并减少 NF-κB 和粘附分子的表达。
An Nrf2-NF-κB crosstalk controls hepatocyte ... - ScienceDirect
2025年2月17日 · We performed AAV8-Cre inducible, hepatocyte-specific knockout of Nrf2, the NF-κB subunit p65, or both genes to determine the individual and combined roles of these transcription factors in the intact liver of male adult mice and after acute CCl 4 injury.
An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant …
3 天之前 · NRF2 is a well-described transcriptional regulator of enzymes of the PPP and antioxidant response. 63 More recently, the NRF2/antioxidant response element pathway was reported to regulate mitochondrial biogenesis through NRF1 regulation 64 and PGC1α, 65 as well as glycogenolysis. 66 These effects are consistent with our observation of ...
Identification and inhibition of PIN1-NRF2 protein–protein
1 天前 · The presence of Pintide led to a 7-, 7-, and tenfold reduction in binding affinity of the fluorescently labelled NRF2 209-222 pSer215, NRF2 402-415 pSer408, and NRF2 571-584 pSer577 NRF2-phospho ...
NF-κB p65、p62和Nrf2信号通路详解,剖析氧化应激与自噬研究 …
2022年9月22日 · 本文为靶点解惑全新主题系列请更换姿势享用! 和之前的靶点解惑有何不同? 信号通路(signal pathway)的提出最早可以追溯到1972年,不过那时被称为信号转换(signal transmission)。 本网站所转载的文章,均来自互联网,旨在传递更多信息。 鉴于互联网的开放性和文章创作的复杂性,我们无法保证所转载的所有文章均已获得原作者的明确授权。 如果您是原作者或拥有相关权益,请与我们联系,我们将立即删除未经授权的文章。 本网站转载文章仅为 …