非核糖体肽合成酶（Nonribosomal peptide synthetase） - 知乎
非核糖体肽的核心骨架由模块化的非核糖体肽合成酶 (Nonribosomal peptide synthetase，NRPS) 组装合成。 一个典型的NRPS由多个模块构成，每个模块包含3个核心功能结构域，分别为： …
非核糖体肽的生物合成研究进展 - 知乎 - 知乎专栏
摘要：非核糖体肽(nonribosomal peptide, NRP)是由多种微生物通过非核糖体肽合成酶(nonribosomal peptide synthetase,NRPS)等催化合成的一类小分子多肽类次级代谢产物,具有抗 …
Nonribosomal Peptide Synthesis—Principles and Prospects
Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that assemble numerous peptides with large structural and functional diversity. These peptides include more …
Evolution-inspired engineering of nonribosomal peptide …
2024年3月21日 · Bacterial NPs, especially those derived from nonribosomal peptide synthetases (NRPSs), have emerged as ideal targets for synthetic biology and have the potential to …
De novo design and engineering of non-ribosomal peptide ... - Nature
2017年12月11日 · Peptides derived from non-ribosomal peptide synthetases (NRPSs) represent an important class of pharmaceutically relevant drugs. Methods to generate novel non …
Structure, Function and Engineering of the Nonribosomal Peptide ...
The nonribosomal peptide synthetase (NRPS) is a highly precise molecular assembly machinery for synthesizing structurally diverse peptides, which have broad medicinal applications. …
Structural Biology of Non-Ribosomal Peptide Synthetases
NRPS Adenylation domains play a key role in peptide natural product biosynthesis. In the assembly line-like choreography, the adenylation domain is the first domain the substrate …
Refining and Expanding Nonribosomal Peptide Synthetase …
Nonribosomal peptide synthetases (NRPSs) are involved in the biosynthesis of numerous peptide and peptide-like natural products that have been exploited in medicine, agriculture, and …
非核糖体多肽合成酶 - 百度百科
nonribosomal peptide synthetase;NRPS 定 义 在细菌和真菌中，绕开核糖体、利用氨基酸及其他化合物(如水杨酸、吡啶羧酸等)、不以信使核糖核酸(mRNA)为模板，也不需转移核糖核 …
非核糖体肽合成中的缩合结构和机制 - 科学网
2024年12月11日 · 非核糖体肽合成酶（NRPSs）是负责许多临床重要天然产物生物合成的巨型酶，从早期现代药物（青霉素、杆菌肽）到目前的阻断药物（克必信、万古霉素）和新批准的治 …