2008年5月1日 · The histological pattern of NSIP (Figure 3) is seen in a range of conditions including connective tissue disease-associated DPLD, in some patients following recovery from ARDS, as a sequelae of COP and in some cases of chronic HP. NSIP is also the typical pattern of injury seen following drug-induced pulmonary fibrosis.

A study of 21 cases of UIP and 32 cases of NSIP found that an HRCT diagnosis of NSIP was associated with a sensitivity of 70% and a specificity of 63% and suggests that NSIP can be distinguished from UIP in most but not all cases by the presence of …

2019年6月4日 · Diffuse parenchymal lung diseases (DPLDs) are a heterogeneous group of about 200 different non‐neoplastic conditions characterised by inflammation and fibrosis of the alveoli, the distal airways, and interstitium from a variety of insults.

2021年9月3日 · 间质性肺疾病 （ILD）/ 弥漫性实质性肺疾病（DPLD）是指由许多已知或未知原因引起的一组弥漫性肺疾病的总称。 它们具有共同的病理特征，如累及部位为肺泡壁和肺泡腔， 病变特征 主要是「炎症和纤维化」，但是这些病变形式、程度和分布不同（下图），形成不同类型的间质性肺炎和不同的临床表型；共同的 临床、病理生理特征 是呼吸困难，肺功能呈换气功能障碍和限制通气功能障碍，影像显示为胸部广泛浸润影。 ILDs的特征通常是炎症和纤维化并存 [1-8]

A large subgroup of patients (34%, n=144) met the IPAF criteria (30% of NSIP, 60% of COP, 20% of IPF, 25% of unclassifiable IIPs and 91% of UCTD-ILD). The most common clinical findings were Raynaud's phenomenon (27.8%), inflammatory arthritis/morning stiffness lasting >60 min (17.4%) and mechanic's hands (10.4%).

We discuss fibrotic NSIP and idiopathic UIP/IPF. We review the 2 most common granulomatous DPLDs, sarcoidosis and hypersensitivity pneumonitis (HP; extrinsic allergic alveolitis).

IPF was characterized by significant distortion and destruction, NSIP showed significant increase in density, and chronic HP presented with consolidations, mild distortion and density. pCLE shows potential as an adjunctive bronchoscopic imaging technique in the differential diagnosis of DPLD.

2012年6月1日 · The term diffuse parenchymal lung disease (DPLD) describes a diverse range of conditions affecting the pulmonary interstitium, which is the space bounded by the alveolar epithelium and the pulmonary capillary bed and including the …

In idiopathic non-specific interstitial pneumonitis (NSIP) cases, the histopathological diagnosis concurred in only 53.3% (8/15), out of which 8 were NSIP, 4 were usual interstitial pneumonia, and 3 were reported as inadequate sampling on histopathology. Conclusion: The MDT plays a crucial role in the diagnosis of DPLDs. Not every pattern ...

To evaluate the clinical spectrum of diffuse parenchymal lung diseases (DPLD) encountered in the Indian setting and to compare idiopathic pulmonary fibrosis (IPF) and connective tissue disease associated DPLD (CTD-DPLD), the two commonest aetiologies.