2024年9月1日 · NTCP will become a promising new target in the therapeutic approach to liver disease. The sodium taurocholate co-transporting polypeptide (NTCP), a bile acids transporter, has been identified as a new therapeutic target for the treatment of liver disease.

2022年5月17日 · Here we report the cryo-electron microscopy structures of human, bovine and rat NTCPs in the apo state, which reveal the presence of a tunnel across the membrane and a possible transport route...

2022年6月20日 · The sodium taurocholate (TC) co-transporting polypeptide NTCP (SLC10A1) is a secondary active membrane transport protein that mediates the uptake of bile salts from the portal blood...

2024年5月15日 · OSH created the National and State Tobacco Control Program (NTCP) in 1999. NTCP encourages coordinated, national efforts to reduce tobacco-related diseases and deaths. The program provides funding and technical support to state and territorial health departments. NTCP funds: 50 states. Washington, DC. Puerto Rico. Guam.

Sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes and a mediator of bile acid transport, has been identified as the receptor responsible for the cellular entry of both HBV and its satellite, hepatitis delta virus (HDV).

2024年5月30日 · CDC established NTCP to provide technical assistance and funding to support comprehensive tobacco control programs in all 50 states, the District of Columbia, and 8 US territories and freely associated states. Overall, NTCP was formed to encourage nationally coordinated, statewide-level efforts to reduce tobacco-related disease and death.

2012年11月13日 · Here, by using near zero distance photo-cross-linking and tandem affinity purification, we revealed that the receptor-binding region of pre-S1 specifically interacts with sodium taurocholate cotransporting polypeptide (NTCP), a multiple transmembrane transporter predominantly expressed in the liver.

Conclusion: NTCP and OATPs contribute to hepatic uptake of conjugated bile acids in mice, whereas the predominant uptake in humans is NTCP mediated. Enterocytes sense highly elevated levels of (conjugated) bile acids in the systemic circulation to induce FGF15/19, which modulates hepatic bile acid synthesis and uptake.

2021年8月1日 · Complementary mechanisms exist to downregulate bile acid uptake during cholestasis. Pharmacological NTCP inhibition is hepatoprotective in cholestasis. HBV/HDV entry requires NTCP and can be inhibited by a pre-S1 mimicking peptide. Inhibition of NTCP could be beneficial in metabolic disorders.

• Sale of tobacco products to and by minors (less than 18 years of age) is prohibited and is a punishable offence. • Sale of tobacco products within 100 yards of Educational Institutions is prohibited and is a punishable offence. • It is mandatory to display the pictorial warnings on tobacco products packages. Loading map...