Sodium/bile acid cotransporter also known as the Na +-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.

2024年12月25日 · SLC10A1 (Solute Carrier Family 10 Member 1) is a Protein Coding gene. Diseases associated with SLC10A1 include Hypercholanemia, Familial, 2 and Familial Hypercholanemia. Among its related pathways are Bile acid …

Sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes and a mediator of bile acid transport, has been identified as the receptor responsible for the cellular entry of both HBV and its satellite, hepatitis delta virus (HDV).

2024年9月1日 · The solute carrier family 10 member 1 (SLC10A1) gene encodes NTCP, which is expressed as a glycoprotein localized to the cell membrane. In hepatic cells, the NTCP is in charge of the transmembrane (TM) transport of bile acids (BAs).

NTCP是乙肝病毒和丁肝病毒的共同受体，介导病毒入侵肝细胞；其对胆汁酸（盐）在体内的调控发挥着重要的作用，主要转运胆盐和硫酸化化合物，同时也能够介导其它底物的转运，例如甲状腺激素、药物和毒素等 [5]。 肝炎药物的研发进展. 据统计，病毒性肝炎每年导致全球约130万人死亡，主要是由于发展为慢性肝病和 肝细胞癌 （hepatocellular carcinoma，HCC）。 其中大约95%的患者死亡是由HBV和丙肝病毒（Hepatitis C Virus，HCV）引起 [6]。 目前全球约有2.5亿人感 …

Sodium taurocholate co-transporting polypeptide (NTCP) is encoded by the solute carrier family 10 member 1 (SLC10A1) gene and is predominantly expressed on the sinusoidal membrane of hepatocytes with the function of hepatic uptake of bile salt, steroid hormones, thyroid hormones, and various bile-acid-conjugated drugs.

2025年1月4日 · Title: The loss of hepatitis B virus receptor NTCP/SLC10A1 in human liver cancer cells is due to epigenetic silencing. SLC10A1 rs2296651 variant (S267F mutation) predicts biochemical traits, hepatitis B virus infection susceptibility and the risk of gallstone disease.

Genetic variation in the HBV receptor gene (NTCP) is significantly associated with a decreased risk of HBV infection in women. genetic variation at the SLC10A1 locus is not likely a major risk factor of persistent HBV infection among Southern Chinese.

2021年8月1日 · NTCP is encoded by the gene SLC10A1 [solute carrier family 10 (sodium/bile acid contransporter) member 1] [5], located at 14q24 in the human genome. The gene is conserved amongst numerous species, and the human protein exhibits 77% amino acid homology with the rat and mouse Slc10a1 gene [5, 6].

Sodium-taurocholate cotransporting polypeptide (Ntcp) and bile salt export pump (Bsep) are two key transporters for hepatic bile acid uptake and excretion. Alterations in Ntcp and Bsep expression have been reported in pathophysiological conditions.