NTCP (sodium taurocholate cotransporting polypeptide)指钠离子-牛磺胆酸共转运蛋白，通常在人肝细胞表面表达。 该受体又称牛磺胆酸钠共转运蛋白。 因发现该受体，北京生命科学研究所资深研究员李文辉博士，于2020年11月12日荣获全球乙肝研究和治疗领域最高奖——巴鲁克·布隆伯格 …

Sodium/bile acid cotransporter also known as the Na +-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.

2024年12月25日 · Protein Symbol: Q14973-NTCP_HUMAN Recommended name: Hepatic sodium/bile acid cotransporter Protein Accession: Q14973 Secondary Accessions: B9EGB6; Q2TU29

2024年12月25日 · Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321).

Na+-牛磺胆酸盐协同转运多肽（NTCP；基因符号 SLC10A1）于 1991 年被克隆，并显示其以钠依赖性方式发挥作用，以有效吸收所有主要的甘氨酸和牛磺酸结合的胆汁酸。 1 NTCP 仅微弱地转运未结合的胆汁酸在随后的几年中，有机阴离子转运多肽 (OATP/SLCO) 家族的成员如人类的 OATP1B1 和 OATP1B3 和小鼠的 Oatp2b1 被确定为负责肝钠非依赖性胆汁酸摄取的转运蛋白，特别是未结合的物种。 NTCP 的特性清楚地表明它是多种物种肝脏胆汁酸摄取的主要候选机制 …

2022年1月17日 · Lately, a noteworthy progress in fighting against HBV has been made by identification of the high-affinity hepatic host receptor for HBV and HDV, namely Na + /taurocholate cotransporting polypeptide (NTCP, gene symbol SLC10A1). Next to its primary function as hepatic uptake transporter for bile acids, NTCP is essential for the cellular entry of ...

2022年6月9日 · Na + /taurocholate cotransporting polypeptide (NTCP, gene symbol SLC10A1) is a hepatic bile acid uptake carrier participating in the enterohepatic circulation of bile acids. Apart from its transporter function, NTCP acts as the high …

Na + /taurocholate cotransporting polypeptide (NTCP, gene symbol SLC10A1) is a hepatic bile acid uptake carrier participating in the enterohepatic circulation of bile acids. Apart from its transporter function, NTCP acts as the high-affinity liver-specific receptor for the hepatitis B virus (HBV), which attaches via its preS1-peptide domain of ...

The Na + -Taurocholate cotransporting polypeptide (NTCP; gene symbol SLC10A1) was cloned in 1991 and shown to function in a sodium-dependent fashion to efficiently take up all the major glycine and taurine-conjugated bile acids. 1 NTCP only weakly transports unconjugated bile acids, and in subsequent years, members of the Organic Anion Transport...

这些作者能够描述两种基本的NTCP构象：第一种构象为开放构象，使得这种蛋白为胆汁盐打开一个大的膜孔，HBV和HDV可以与之结合；第二种构象为“封闭”构象，防止被这两种病毒识别。 开放膜孔状态和面向内部状态之间的异构化，图片来自Nature, 2022, doi:10.1038/s41586-022-04723-z。 第一种“开放”构象非常令人惊讶，因为没有其他已知的分子 转运蛋白 形成这样一个“广泛开放”的膜孔。 反过来，第二种构象可能有助于找到防止HBV和HDV感染的抗病毒分子。 这些作者 …