We have developed a convenient software tool for estimating the TCP or NTCP arising from differential (frequency) dose‐volume histograms (DDVHs). The program, TCP_NTCP_CALC, was designed to amalgamate relevant current radiobiological modeling knowledge and make it accessible to clinicians, treatment planners, and researchers.

Generally, NTCP models attempt to reduce complicated dosimetric and anatomic information to a single risk measure. Most models fall into one of three categories: DVH-reduction models, tissue architecture models, and multiple-metric (‘multi-metric’) models.

2019年6月1日 · Mathematical models of normal tissue complication probability (NTCP) able to robustly predict radiation-induced morbidities (RIM) play an essential role in the identification of a personalized optimal plan, and represent the key to maximizing the benefits of technological advances in radiation therapy (RT).

What dosimetric features should be restricted to keep normal tissue complication risk low? What guidance is available? How does it apply to individual clinical practice? Volume effects are important!

2012年3月1日 · The Normal Tissue Complication Probability (NTCP) for rectum is usually defined for late rectal bleeding. This study calculates NTCP parameter values for additional rectal toxicity endpoints observed in clinical practise.

Awareness of optimal model parameters is vital for estimating normal tissue complication probability (NTCP) for different algorithms. The aim is to determine the NTCP parameter values for different DCAs in left-sided breast radiotherapy, …

A convenient computational module has been developed for estimating the TCP and the NTCP arising from a dose distribution calculated by a treatment planning system, and characterized by differential (frequency) dose-volume histograms (DDVHs).

2022年2月2日 · Modelling radiotherapy response is a multidimensional challenge. Both sides of the therapeutic ratio; tumour control probability (TCP) and normal tissue complication probability (NTCP) need to be accurately predicted to personalise radiation prescription and manage...

The predicted NTCP values for pneumonitis vary between 0.20 and 0.24 or 0.35 and 0.48 across the investigated dose algorithms depending on the chosen model parameter set. The influence of the use of density correction in the dose calculation on the predicted NTCP values depends on the specific dose calculation algorithm and the model parameter set.

2023年3月1日 · These translate into large differences of NTCP values, with maximum NTCP ranges of 35.2% to 93.4% for the saliva endpoint, 39.4% to 90.4% for the pneumonitis endpoint, and 5.4% to 99.3% for the rectal bleeding endpoint.