2024年12月25日 · NTN1 (Netrin 1) is a Protein Coding gene. Diseases associated with NTN1 include Mirror Movements 4 and Mirror Movements 1. Among its related pathways are Netrin-1 signaling and Nervous system development. An important paralog of this gene is NTN3. Netrins control guidance of CNS commissural axons and peripheral motor axons.

Netrin-1 is a protein that in humans is encoded by the NTN1 gene. [5][6] Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development.

2024年6月28日 · Netrin-1 (NTN1) was found up-regulated in nerve stump after peripheral nerve injury (PNI). Herein, we demonstrated that NTN1-high endothelial cells (NTN1+ECs) were the critical component of vascular niche, fostering angiogenesis, axon regeneration, and repair-related phenotypes.

2024年11月27日 · Netrin-1 elicits metastatic potential of non-small cell lung carcinoma cell by enhancing cell invasion, migration and vasculogenic mimicry via EMT induction. Zhang X, et al. Cancer Gene Ther, 2018 Feb. PMID 29234153. The neuroimmune guidance cue netrin-1: a new therapeutic target in cardiovascular disease.

2015年7月8日 · In various somatic cells, we found that reprogramming is accompanied by a transient transcriptional repression of Netrin-1 mediated by an Mbd3/Mta1/Chd4-containing NuRD complex. Mechanistically,...

Results demonstrate that NTN1 is an important regulator of stemness and motility of glioblastoma cells. Furthermore, it deciphers a novel mechanism where NTN1 activates Notch signaling and subsequent stemness in invasive glioblastoma cells.

2025年1月25日 · Netrin-1 (NTN1) is a laminin-related secreted protein involved in axon guidance and cell migration. Previous research has established a significant connection between NTN1 and nervous system...

2024年9月15日 · Netrin-1(NTN1), a kind of secretory protein related to laminin, guides the direction of nerve growth by binding with its receptor, which can promote early synapse formation in addition to axon guidance function. NTN1 and its receptors (Unc5A-D) are well known to be involved in inflammation, tumor growth and axon regeneration [9,10].

Netrin 属于层粘连蛋白相关分泌蛋白家族。 该基因的功能尚未确定；然而，netrin 被认为参与了发育过程中的轴突导向和细胞迁移。 netrin 的突变和表达缺失表明 netrin 的变异可能与癌症的发展有关。 [RefSeq 提供，2008 年 7 月] Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development.

NTN1，即轴突生长诱向因子1，是一种蛋白质，由α-螺旋结构组成，并由NTN1基因编码。 这种蛋白质在神经元的发育过程中扮演着重要的角色。 NTN1通过与其受体识别并结合，引导神经元轴突的生长和突触的形成。 这种结合通常依赖于Ca2+离子的存在，通过受体激活内源性信号传导通路，最终影响神经元的发育和功能。 此外，Netrin-1能够抑制肿瘤细胞的凋亡（细胞死亡），并促进新血管生成以及控制成纤维细胞。 Netrin-1还涉及上皮间质转化（EMT）过程。 EMT与肿瘤 …