NU6027 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with K i s of 2.5 µM and 1.3 µM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea …

2011年7月5日 · NU6027 is a potent inhibitor of cellular ATR activity (IC 50 =6.7 μ M) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.

2011年7月5日 · NU6027 inhibited ATR. We determined cellular ATR and CDK2 inhibition by NU6027, modulation of DNA damage-induced cell cycle arrest, repair by HR, enhancement of …

2011年7月26日 · NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and PARP inhibitors. It provides proof of …

NU 6027 inhibits both CDK1 and CDK2 with IC 50 values of 2.9 and 2.2 µM, respectively. 1 It has been shown to inhibit cellular ataxia telangiectasia mutated and Rad3- related kinase activity …

NU6027是一种有效的ATR/CDK抑制剂，抑制 CDK1/2， ATR 和 DNA-PK 时， Ki 分别为2.5 μM/1.3 μM， 0.4 μM和 2.2 μM ，进入细胞时比6-氨基嘌呤类抑制剂更容易。 NU6027抑制cdk1 …

ATR/CDK Inhibitor, NU6027 The ATR/CDK Inhibitor, NU6027, also referenced under CAS 220036-08-8, controls the biological activity of ATR/CDK. This small molecule/inhibitor is …

2011年7月7日 · NU6027 is a potent inhibitor of cellular ATR activity (IC 50 =6.7 μ M) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. NU6027 …

2011年7月26日 · Cell cycle effects and chemo- and radiopotentiation by NU6027 were determined in MCF7 cells and the role of mismatch repair and p53 was determined in …