2024年12月25日 · NUP133 (Nucleoporin 133) is a Protein Coding gene. Diseases associated with NUP133 include Galloway-Mowat Syndrome 8 and Nephrotic Syndrome, Type 18. Among its related pathways are Transport of the SLBP independent Mature mRNA and EML4 and NUDC in mitotic spindle formation.

2018年5月22日 · Souquet et al. report that Nup133, a structural component of the nuclear pore complex (NPC), is dispensable for NPC scaffold formation during post-mitotic and interphase pore assembly in embryonic stem cells. Yet, they also find that Nup133’s central domain is required for a properly configured nuclear basket in all NPCs.

Nuclear pore complex protein Nup133, or Nucleoporin Nup133, is a protein that in humans is encoded by the NUP133 gene. [5][6][7] The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells.

接下来，该研究通过基因敲除核孔蛋白基因nup133和elys，或转基因过表达nup133，成功干扰或促进了核孔复合体在早期胚胎中的组装。在突变体胚胎中，母源转录因子的入核被显著干扰，合子基因的表达明显延迟；而转基因过表达则明显促进了转录因子的入核与合子 ...

This gene has 4 transcripts (splice variants), 207 orthologues and is associated with 5 phenotypes. Ubiquitous expression in testis (RPKM 11.8), brain (RPKM 11.8) and 25 other tissues. 核膜在真核细胞中产生不同的核和细胞质区室。 它由两个由核孔穿孔的同心膜组成，大型蛋白质复合物形成水通道以调节细胞核和细胞质之间大分子的流动。 这些复合物由至少 100 个不同的多肽亚基组成，其中许多属于核孔蛋白家族。 由该基因编码的核孔蛋白显示出与其他核 …

Here, we generated an in vitro model of NUP133 -linked nucleoporopathies using CRISPR/Cas9-mediated genome editing in human podocytes. Transcriptome, nuclear pore assembly, and cytoskeleton regulation of NUP133 loss-of-function, mutant, …

2025年1月4日 · Title: Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. The significant topological differences between Nup107 and Nup133 suggest that helical nucleoporin domains of the nuclear pore complex scaffold fall in different classes and fulfill largely nonredundant functions.

2008年6月20日 · To gain insight into the intricate assembly of the NPC, we have solved the crystal structure of a protein complex between two nucleoporins, human Nup107 and Nup133. Both proteins form elongated structures that interact tightly …

2022年4月7日 · Transcriptome, nuclear pore assembly, and cytoskeleton regulation of NUP133 loss-of-function, mutant, and wild-type podocytes were analyzed. Loss of NUP133 translated into a disruption of the nuclear pore, alterations of the podocyte-specific transcriptome, and impaired cellular protrusion generation.

2018年5月22日 · Nup133 belongs to the Y-complex, a key component of the nuclear pore complex (NPC) scaffold. Studies on a null mutation in mice previously revealed that Nup133 is essential for embryonic development but not for mouse embryonic stem cell (mESC) proliferation. Using single-pore detection and average N …