The Nup and SUMO E3-ligase Nup358/RanBP2 are the major components of the cytoplasmic filaments of the NPC. In this study, we perform a structure-function analysis of Nup358 and …

2024年6月5日 · We report that Nup358, a nucleoporin linked to several myeloid disorders, is required for the developmental progression of early myeloid progenitors.

In the present study, we evaluate changes in the expression levels of several nucleoporins and show that the amount of Nup358/RanBP2 within individual NPCs increases during muscle …

Transmission electron microscopy (TEM) analysis of purified Nup358/RanBP2 revealed a ∼36-nm filamentous structure, and depletion of Nup358 from Xenopus egg extracts caused assembly …

四个Nup358夹在内侧和外侧Y复合体周围，以稳定CR，而第五个Nup358位于这个夹起结构的中心位置。 AlphaFold还预测了Nup358的同源 寡聚体 （可能是 五聚体 ）的卷曲螺旋结构域，这 …

1995年6月9日 · Electron microscopy of immunogold-decorated rat liver nuclear envelopes sublocalized the 358-kDa protein at (or near) the tip of the cytoplasmic fibers of the nuclear …

Nup358 is the first nucleoporin shown to contain bind-ing sites for two ofthree soluble nuclear transport fac-tors so far isolated, namely karyopherin and Ran-GTP. Bidirectionaltraffic of …

2010年12月7日 · Nup358 plays a supportive role in CRM1-mediated nuclear export by stimulating CRM1 recycling . Nup358 provides a platform for the disassembly of CRM1 export complexes …

2009年4月15日 · Nup358 (also known as RanBP2), a component of the cytoplasmic filaments of the nuclear pore complex, has been implicated in various nucleocytoplasmic transport …

2008年2月27日 · In vertebrate cells, the nucleoporin Nup358/RanBP2 is a major component of the filaments that emanate from the nuclear pore complex into the cytoplasm. Nup358 forms a …