The nuclear receptor 4A2 (NR4A2) (nuclear receptor subfamily 4 group A member 2) also known as nuclear receptor related 1 protein (NURR1) is a protein that in humans is encoded by the NR4A2 gene. [5] NR4A2 is a member of the nuclear receptor family of …

2013年10月15日 · Emerging evidence indicates that impaired NURR1 function might contribute to the pathogenesis of PD: NURR1 and its transcriptional targets are downregulated in midbrain DA neurons that express...

The aims of this study were to determine (1) whether NURR1 gene expression in PBL is specifically reduced in PD as compared with HC and NDC; (2) whether the NURR1 expression can be used to help identify PD, and (3) whether age, gender, anti-PD medications, or disease severity affects the expression of NURR1.

Nurr1是NR4A家族成员，与II型核受体不同，它可以直接结合DNA，以单体或者 同源二聚体 的形式调节转录，当然也可以与RXR结合成异源二聚体发挥作用。Nurr1在大脑中表达水平很高，使用Nurr1完全敲除小鼠和部分敲除小鼠均证实了Nurr1在其中的关键作用：多巴胺能神经 ...

2020年7月3日 · Here, we report the discovery of several structurally diverse non-steroidal anti-inflammatory drugs as inverse Nurr1 agonists demonstrating that Nurr1 activity can be regulated bidirectionally....

2023年7月18日 · An optimized agonist of Nurr1, 4A7C-301, protects dopamine neurons against environmental and genetic risk factors of Parkinson’s disease (PD) in vitro, and improves both motor and non-motor ...

2022年6月27日 · Nuclear receptor-related factor 1 (NURR1), an orphan member of the nuclear receptor superfamily of transcription factors, is a major risk factor in the pathogenesis of PD, and changes in NURR1 expression can have a detrimental effect on cellular metabolism.

NR4A2 is a nuclear receptor and a transcription factor, with distinctive physiological features. In the cell nuclei of the central nervous system, it is widely expressed and identified as a crucial regulator of dopaminergic (DA) neuronal differentiation, survival, and maintenance.

摘要：Nurr1属于孤儿核受体的超家族,人类Nurr1基因位于2号染色体,在中枢多巴胺能系统中高度表达,与中脑多巴胺能神经元的发育、存活密切相关.本文对Nurr 1的分子结构、分布及生理功能作一综述. [1] 佚名. Prepro-neurturin基因的克隆及其在COS-7中的表达 [J]. 中国神经科学杂志 . 2001 ,17(4).358-361. [2] 叶民 , 陈生弟 , 汪锡金 ,等. 体外诱导骨髓基质干细胞治疗帕金森病大鼠模型的研究 [J]. 中华神经科杂志 . 2005 ,38(10).624-627. DOI: 10.3760/j.issn:1006-7876.2005.10.007 . …

Based on the unique dual role of the nuclear orphan receptor Nurr1 for development and maintenance of mDA neurons and their protection from inflammation-induced death, we hypothesize that Nurr1 can be a molecular target for neuroprotective therapeutic development for …