002105 NZO/HlLtJ NZO inbred mice and strains derived from them develop severe obesity, and are thus useful for studying obesity and Type 2 diabetes.

2002年7月1日 · New Zealand Obese (NZO)/HlLt male mice exhibit a polygenic obesity and approximately 50% develop type 2 diabetes. This strain is known to produce a variety of autoantibodies, including...

In this context, we investigated whether New Zealand obese (NZO/HlLtJ) mice, which have anatomic and functional characteristics similar to those of obese patients with OSAS, suffer from obstructive sleep apnea and could therefore be used as a pathophysiological model of OSAS.

Here, we show that New Zealand obese (NZO) mice display similar metabolic characteristics such as obesity, leptin insensitivity, glucose intolerance, and IR. Importantly, NZO mice are poor breeders; however, the mechanism for this has not been investigated.

1979年5月24日 · THE New Zealand obese (NZO) mouse is characterised by obesity, hyperinsulinaemia, insulin resistance and mild glucose intolerance 1–8. It has been thought of as a model of...

Carbohydrate-free diet prevents hyperglycaemia and beta cell destruction in the New Zealand Obese (NZO) mouse model. Here we have used a sequential dietary regimen to dissociate the effects of obesity and hyperglycaemia on beta cell function and integrity, and to study glucose-induced alterations of key transcription factors over 16 days.

2020年5月6日 · Here, we compared the metabolic changes in pregnant normal NMRI mice with those in New Zealand obese (NZO) mice. Male animals of this strain are an established model of T2DM, whereas female mice of this strain are protected from hyperglycemia and β‐cell death.

These data suggest that MR induces FGF21 and protects NZO mice from high-fat diet-induced glucose intolerance and type 2 diabetes. The normoglycemic phenotype in vegans and vegetarians may be caused by induced FGF21.

The New Zealand Obese (NZO) mouse was studied as a potential model for autoimmune diabetes. NZO mice develop obesity, glucose intolerance, and insulin resistance, and have low-titer IgM antibodies to the insulin receptor. It is shown that they have circulating antibodies to both native DNA and denat …

2004年7月1日 · 大约50%的NZO/HlLt男性发展为慢性胰岛素抵抗型2型糖尿病综合征，并伴有2个不寻常的特征:富含B淋巴细胞的岛周浸润和抗胰岛素受体自身抗体(AIRAs)的发展。