Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone -mediated oxidation of dihydroorotate to orotate, in de …

2019年4月2日 · In this report we describe the discovery and characterization of BAY 2402234 - a novel, potent, selective and orally bioavailable DHODH inhibitor that shows monotherapy efficacy and differentiation...

2024年12月24日 · DHDH (Dihydrodiol Dehydrogenase) is a Protein Coding gene. Diseases associated with DHDH include Developmental Dysplasia Of The Hip 1 and Developmental Dysplasia Of The Hip 2. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity.

2024年11月8日 · Through bioinformatics analysis, we found that a metabolic enzyme, dihydrodiol dehydrogenase (DHDH), which is highly expressed in nonimmune-inflamed TNBC, could deplete D-xylose in the tumor microenvironment to inactivate the immune response and cytotoxic T …

Findings: Mechanistically, DHDH mediated the synthesis and depletion of the substrate D-xylose and inhibited the activation of the proteasome subunit beta type 9 (PSMB9) and further induction of the immune response.

2020年6月1日 · Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In mammalian cells, DHODH is localized in mitochondria, linked to the respiratory chain via the coenzyme Q pool.

2025年2月8日 · Survival was significantly better in gastric cancer patients with low DDH expression. Title: Overexpression of dihydrodiol dehydrogenase as a prognostic marker in …

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Keywords: Acute myeloid leukemia; Brequinar; DHODH; differentiation; metabolism; nucleotides; pyrimidines; therapeutic window.

2025年2月8日 · Clinical resource with information about DHDH, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.