2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene. [5] [6] This gene encodes a member of the 2-5A synthetase family, which include essential proteins involved in the innate immune response to viral infection.

2024年12月25日 · OAS1 (2'-5'-Oligoadenylate Synthetase 1) is a Protein Coding gene. Diseases associated with OAS1 include Immunodeficiency 100 With Pulmonary Alveolar Proteinosis And Hypogammaglobulinemia and Infantile-Onset Pulmonary Alveolar Proteinosis-Hypogammaglobulinemia.

2014年7月18日 · The OAS1, OAS2 and OAS3 proteins are all active enzymes that can generate 2′–5′-linked oligoadenylates, whereas OASL is devoid of 2′–5′-linked oligoadenylate synthase activity.

2020年7月27日 · 2'-5'-Oligoadenylate synthetases (OAS) are innate immune sensors of cytosolic double-stranded RNA (dsRNA) and play a critical role in limiting viral infection. dsRNA binding induces allosteric structural changes in OAS1 that reorganize its catalytic center to promote synthesis of 2'-5'-oligoadenylate and thus activation of endoribonuclease L ...

Gene ID: 4938, updated on 8-Feb-2025. This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis.

2020年6月17日 · 2′-5′-Oligoadenylate synthetases (OAS) are innate immune sensors of cytosolic double-stranded RNA (dsRNA) and play a critical role in limiting viral infection. dsRNA binding induces allosteric structural changes in OAS1 that reorganize its catalytic center to promote synthesis of 2′-5′-oligoadenylate and thus activation of endoribonuclease L. Sp...

The human OAS1 (hOAS1) gene produces multiple possible isoforms due to alternative splicing events and sequence variation among individuals, some of which affect splicing. The unique C-terminal sequences of the hOAS1 isoforms could differentially ...

2024年3月12日 · Here, we show that human, but not mouse, OAS1 inhibits SARS-CoV-2 replication through its canonical enzyme activity via RNase L. In contrast, both mouse and human OAS1 protect against West Nile virus infection by a mechanism distinct from canonical RNase L …

We identified four de novo heterozygous OAS1 gain-of-function variants in six patients with a polymorphic autoinflammatory immunodeficiency characterized by recurrent fever, dermatitis, inflammatory bowel disease, pulmonary alveolar proteinosis, and hypogammaglobulinemia.

OAS1–3 loci possess COVID-19-associated SNPs and respond to SARS-CoV-2. Positions and GWAS p-values for SNPs at the OAS1, OAS3, and OAS2 loci. GWAS results of confirmed COVID-19 cases with very severe respiratory conditions (a), hospitalized patients with COVID-19 (b), and all patients with COVID-19 (c) (reported by COVID-19 Host Genome Initiative groups).