2018年2月1日 · To address these challenges, we developed methodologies to prevent ex vivo release of TGF-β1 and to quantify active TGF-β1. We then used these techniques to measure TGF-β1 in healthy controls and patients with heart failure (HF) before and after insertion of left ventricular assist devices (LVAD).

To address these challenges, we developed methodologies to prevent ex vivo release of TGF-β1 and to quantify active TGF-β1. We then used these techniques to measure TGF-β1 in healthy controls and heart failure (HF) patients before and after insertion of …

2025年1月1日 · Elevated TGF-β levels can serve as a diagnostic biomarker for early detection, prognosis, and treatment response monitoring. Various therapeutic strategies, including small molecule inhibitors and monoclonal antibodies, aim to modulate TGF-β signaling, addressing its pro-tumorigenic effects [73].

2017年5月12日 · TGF-β 1 –dependent cardiomyocyte depolarization resulted from electrotonic crosstalk with myofibroblasts as demonstrated by immediate normalization of cardiomyocyte electrophysiology after targeted disruption of coupled myofibroblasts and by cessation of ectopic activity of cardiomyocytes coupled to myofibroblasts during pharmacological gap ...

Transforming growth factor-β (TGF-β) is a multi-factorial peptide growth factor that has a vital role in the regulation of cell growth, differentiation, inflammation, and tissue repair. Quantification of biologically active TGF-β levels in tissues ...

2011年1月1日 · After thoracic aortic constriction, inhibition of TGF-β1 attenuated cardiac fibrosis and improved diastolic function without affecting cardiac hypertrophy. 14 Several studies have also demonstrated increased inflammation during the acute and chronic phases of pressure overload–induced heart failure. 15 For example, increased cardiac ...

First, we discuss vascular development and TGF-β signaling, followed by the mechanisms that are at the basis of TGF-β’s control of vascular function, its effects on endothelial cells (ECs), smooth muscle cells (SMCs), and pericytes, and how a misbalance in TGF-β signaling leads to vascular dysfunction.

The expression levels of serum TGF-β1, p2PSA and PSA are related to PCa and are independent risk factors for PCa. The combined detection of the three groups can improve the diagnostic efficacy of PCa. Combined testing improves diagnostic accuracy for prostate cancer, allows for early intervention, a …

2020年9月12日 · I just remembered about tgf’s old brand obdurate. What happened to it? Tf dooes obdurate even mean?

Transforming Growth Factor-beta (TGF-β) is a multifunctional cytokine that exerts its biological effects through a complex process of activation and signaling. Initially synthesized in an inactive form bound to latency-associated peptide (LAP), TGF-β …