The ob/ob or obese mouse is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese. It is an animal model …

ob是瘦素的编码基因，利用EGE技术将ob基因2、3号外显子敲除制备的B-ob/ob小鼠，具有肥胖症和高血糖症状，是研究高血糖和肥胖症的有力模型。 Ob/ob mouse 是一种突变小鼠，过量进 …

The obese diabetic mouse (ob/ob) is an excellent model for the study of obesity and diabetes as it has a longer lifespan and less severe clinical symptoms than the diabetic mouse (db/db).

2021年6月28日 · Ob/ob mice are characterized by a mutation of the obese (ob) gene encoding leptin, whereas the db/db mice have a mutation of the diabetes (db) gene encoding for the …

2016年8月10日 · Ob/ob mouse 是一种突变小鼠，过量进食，导致非常肥胖。 它是一种2型糖尿病模型。 突变基因ob的证明使我们发现了瘦素，其对食欲的控制很重要。 第一只Ob/ob mouse …

This study was aimed at characterization of PDN in leptin-deficient (ob/ob) mice, a model of type 2 diabetes with relatively mild hyperglycemia and obesity. ob/ob mice ( approximately 11 weeks …

This review summarizes key aspects of what has been learned about the physiology of leptin deficiency as it can be observed in obese-hyperglycemic ob/ob mice. These mice lack …

000632 B6.Cg- Lep ob /J Mice homozygous for the obese spontaneous mutation, Lep ob (commonly referred to as ob or ob/ob ), exhibit obesity, hyperphagia, transient hyperglycemia, …

2017年9月8日 · Leptin-deficient mice (ob/ob) are widely employed to investigate obesity. Aim of this study was to provide a micro-ultrasound (μUS) longitudinal evaluation of the ob/ob mouse...

There remains a need for robust mouse models of diabetic nephropathy (DN) that mimic key features of advanced human DN. The recently developed mouse strain BTBR with the ob/ob …