Characteristics: Growth at the permissive (33 Celsius) temperature results in dedifferentiation of the cells and accelerated proliferation. At the restrictive temperature (39 Celsius) cell proliferation halts in about 48h.

2024年11月26日 · Using different approaches, Kaplan et al. and Merz et al. identified an OC1 enhancer regulating OC1 expression during differentiation of human pancreatic cells. An effect of decreased OC1 on endocrine differentiation is not unexpected given that it activates the pro-endocrine transcription factor gene, neurogenin 3, 10 but the mechanism for the ...

The House Ear Institute-Organ of Corti 1 (HEI-OC1) is one of the few, and arguable the most used, mouse auditory cell line available for research purposes. Originally proposed as an in vitro system for screening of ototoxic drugs, it has been used to investigate, among other topics, apoptotic pathwa …

2016年5月1日 · Our results indicate that the HEI-OC1 cells respond to different pharmacological drugs in a complex way, with a distinctive dose- and time-dependent combination of all the mechanisms under study. Moreover, they suggest that the responses could be unique to …

Here, we describe how to culture HEI-OC1 cells and how to use them in some typical assays, such as cell proliferation, viability, death, autophagy and senescence, as well as how to perform patch-clamp and non-linear capacitance measurements.

小鼠耳蜗毛细胞系House Ear Institute-Organ of Corti 1（HEI-OC1）来源于小鼠耳蜗。 该细胞用于研究小鼠听觉研究，被认为是一种用于筛选耳毒性药物的体外系统，已被用于研究药物激活的凋亡途径、自噬、衰老、炎症反应、细胞分化、药 物的遗传和表观遗传的作用 ...

2021年7月6日 · Several studies have shown how different cell lines can influence the differentiation of stem cells through co-culture systems. The House Ear Institute-Organ of Corti 1 (HEI-OC1) is...

2024年9月30日 · We found that H 2 O 2 treatment induced oxidative stress injury in HEI-OC1 cells, as evidenced by decreased cell viability and increased total intracellular and mitochondrial ROS levels (p < 0.05). TXNIP expression was elevated, and NLRP3 and NF …

HEI-OC1 cells (M8-0401, OriCell, Guangzhou, China), a mouse auditory cell line, were utilized in this study as an in vitro system to assess the functional response of Bhlhe40 in oxidative injury to cochlear hair cells.

HEI-OC1是为数不多的用于研究目的的小鼠听觉细胞系之一。 这些细胞最初被认为是一种用于筛选耳毒性药物的体外系统，已被用于研究药物激活的凋亡途径、自噬、衰老、细胞保护机制、炎症反应、细胞分化、药物的遗传和表观遗传效应、缺氧、氧化和内皮细胞的作用，耳蜗中分子通道和受体的表达。 在耳蜗毛细胞的其他几个重要标志物中，HEI-OC1细胞在耳蜗毛细胞内表达Prestin蛋白，这是外毛细胞的典型运动蛋白。 因此，HEIOC1细胞对于阐明这种重要听觉蛋白的新功能和 …