Structural and functional changes within the brain have long been implicated in the pathophysiology of OCD. Cortical and sub-cortical brain regions comprise a series of functionally relatively segregated circuits, that may play different roles in thoughts and behaviors 3.

Dysregulation of glutamate levels may disrupt the balance of communication within the brain circuits implicated in OCD. Understanding the intricate interplay between brain regions, neural pathways, and neurotransmitters in OCD can help researchers and clinicians develop more targeted and effective treatments for this complex disorder.

2021年8月16日 · Human neuroimaging studies have consistently highlighted abnormal activity patterns in prefrontal cortex (PFC) regions and connected circuits in OCD during both symptom provocation and...

2025年3月20日 · We review the key studies from recent years with the aim to aggregate and condense findings along both spatial and temporal domains. The result is a concept that anatomically defines a circuit that is likely dysfunctional in patients with typical OCD phenotypes, and which may be adaptively targeted using DBS to maximally improve symptoms.

Three brain areas – the orbitofrontal cortex (OFC), the anterior cingulate cortex (ACC), and the head of the caudate nucleus – have been consistently implicated in a large number of resting, symptom provocation, and pre/post-treatment studies of adults with OCD.

2021年1月7日 · Studies with treatment-resistant OCD patients indicate that invasive neuromodulation techniques, such as deep-brain stimulation (DBS), may improve fronto-limbic circuit function.

2025年3月14日 · Explore how deep brain stimulation modulates neural circuits in OCD, offering insights into targeted brain regions and observed changes in symptom patterns. ... Obsessive-compulsive disorder (OCD) is a debilitating condition marked by intrusive thoughts and repetitive behaviors that severely impact daily life. While cognitive-behavioral therapy ...

2024年10月31日 · However, research shows that the roots of the disorder are within the brain’s neural circuits. This review introduces the critical brain anatomy and neural circuitries related to OCD, unpacking the neural roots that cause OCD.

At the heart of OCD lies the cortico-striato-thalamo-cortical (CSTC) loop, a neural circuit that plays a crucial role in decision-making, habit formation, and behavioral control. Studies have shown that disruption in this circuit may result in the characteristic symptoms of OCD. Key brain regions involved in this circuit include:

Obsessive-Compulsive Disorder (OCD) may involve an imbalance between goal-directed and habitual learning systems, and this study investigates the structural and functional brain networks underpinning these systems in OCD. Using predefined brain regions, structural and functional connectivity networks were constructed, and methods such as ...