Obsessive-compulsive disorder (OCD) has been seen to run in families and genetics help to understand its heritability. In this review, we summarize older studies which focused on establishing the familial nature of OCD, including its various dimensions of symptoms, and we focus on recent findings from studies using both the candidate gene ...

2010年12月2日 · Obsessive-compulsive disorder (OCD) is a serious psychiatric disorder that affects approximately 2% of the populations of children and adults. Family aggregation studies have demonstrated that OCD is familial, and results from twin studies demonstrate that the familiality is due in part to genetic factors.

12 小时之前 · Scientists have been investigating how OCD runs in families, which genes may be involved, and how genetic expression can be influenced by external factors. Heritable Patterns. Genetic predisposition plays a substantial role in OCD, with heritability estimates ranging from 45% to 65% in children and adolescents and approximately 27% to 47% in ...

2024年3月28日 · To characterize the genetic underpinnings of OCS and its genetic relationship to OCD, we conducted the largest genome-wide association study (GWAS) meta-analysis of parent- or self-reported...

2021年7月21日 · We focus on discoveries stemming from technical and methodological advances of the past five years and present a synthesis of human genomics research on OCD. On balance, reviewed studies...

2021年5月25日 · Results: OCD is a heritable, polygenic disorder with contributions from both common and rare variants, including de novo deleterious variations. Multiple studies have provided reliable support for a large additive genetic contribution to liability to OCD, with discrete OCD symptom dimensions having both shared and unique genetic risks.

2021年6月28日 · Columbia research finds that some cases of OCD are caused by damaging gene variants that, while rare, provide a needed starting point for the development of better therapeutics.

2020年4月27日 · Obsessive-compulsive symptoms (OCS) in the population have been linked to obsessive-compulsive disorder (OCD) in genetic and epidemiological studies. Insulin signaling has been implicated in...

2024年3月8日 · The exact causes of obsessive-compulsive disorder (OCD) are not fully understood, but it is clear that genetics play a role. Current evidence suggests that genetic factors interact with environmental variables to affect the risk of a person developing OCD.

OCD is a heritable, polygenic disorder with contributions from both common and rare variants, including de novo deleterious variations. Multiple studies have provided reliable support for a large additive genetic contribution to liability to OCD, with discrete OCD symptom dimensions having both shared and unique genetic risks.