2024年2月28日 · Immunostaining revealed that Sox9 EC-OE mice displayed an increased number of platelet-derived growth factor receptor α (PDGFRα)–expressing fibroblasts 30 days after overexpression of Sox9 in ECs, indicating that EC SOX9 triggered fibroblast expansion.

2025年3月20日 · In this study, we identified Lactobacillus plantarum WCFS1 (Lp), a commensal strain with a natural affinity for the OE and engineered it to function as a vector for cerebral drug delivery. Upon intranasal administration, Lp released specific payload molecules within the OE, with subsequent transport and accumulation in the brain.

2018年10月1日 · The ob/ob-SIRT5 OE mice showed decreased malonylation and succinylation, improved cellular glycolysis, suppressed gluconeogenesis, enhanced fatty acid oxidation, and attenuated hepatic steatosis. A total of 955 malonylation sites on 434 proteins and 1377 succinylation sites on 429 proteins were identified and quantitated.

2018年10月15日 · Thyroid-hormone responsive (THRSP) overexpressing (OE) mice exhibits inattention, but not hyperactivity and impulsivity. THRSP OE mice have elevated striatal dopamine-related gene (DAT, TH, and dopamine D1 and D2 receptors) expression levels. Methylphenidate improves attention in THRSP OE mice.

2024年11月18日 · To elucidate the underlying molecular mechanisms of AP1AR-DT OE-induced anxiety- and depression-like states in mice, we performed RNA-seq using RNA extracted from mPFCs of AP1AR-DT OE mice or control mice to identify DEGs.

2018年7月19日 · Here we show, using mice with disease-relevant alterations in DA signaling (D2R-OE mice), that deficits in working memory (WM) are associated with impairments in the WM-dependent firing...

2025年3月5日 · Enriched for neural factors, the X harbors 5% of our genome and has been largely understudied in the aging brain. In female mammals with two X’s, one is silenced through X chromosome inactivation (XCI), resulting in an active (Xa) and inactive X (Xi) ().While XCI is thought to equalize X-linked gene expression between XX and XY cells, select genes from the Xi escape inactivation, to varying ...

Corticotropin-releasing factor (CRF)-overexpressing (OE) mice are a genetic model of chronic stress with elevated brain CRF and plasma corticosterone levels and Cushing’s syndrome. The brain structural alterations in the CRF-OE mice, however, are not well known.

3 天之前 · In vivo experiments were conducted with mice divided into four groups after different treatments: control group, model group, Model + PKM2-OE group, and Model + PKM2-KD group.

1 天前 · The successfully constructed Thy1-OE NK cells had significantly higher effector molecules and induced greater HSC apoptosis than the control NK cells. It revealed a pattern of hepatic NK cells in a mouse model of schistosomiasis. ... Hepatic NK cells were isolated from uninfected mice and mice infected for four and six weeks. The NK cells ...