NF-κB p65 and SETDB1 expedite lipopolysaccharide
2023年2月1日 · NF-κB p65 and SETD1B synergistically induce histone methylation to upregulate IRF7. This study offers a theoretical basis for preventing intestinal inflammation. Macrophages …
NF-κB regulates brown adipocyte function through suppression of …
2022年3月1日 · The brown adipocytes of mice with NF-κB activation (p65 overexpression, p65-OE) exhibited a set of opposite alterations with a reduction in apoptosis, an increase in cristae …
p65蛋白：生物信号传导的关键角色与疾病治疗的新靶点
2024年12月25日 · p65磷酸化位点对PKC介导的信号转导通路具有重要的调控作用，磷酸化后的p65蛋白在核转运、DNA结合和转录活性等方面发生显著变化，进而影响下游基因的表达。
RNF182 induces p65 ubiquitination to affect PDL1 transcription …
RNF182 overexpression suppressed the malignant properties of LUAD cells, and it promoted p65 ubiquitination and protein degradation. p65 activated PDL1 transcription.
CREB3 facilitates Donafenib resistance in ... - ScienceDirect
2024年6月1日 · CREB3 promotes Donafenib resistance in HCC cells by elevating p65 expression. Drug resistance greatly limits the therapeutic effect of a drug. This study aimed to explore the …
Enhancement of a prime editing system via optimal recruitment of …
2023年1月17日 · Prime editing is a versatile gene editing tool that enables precise sequence changes of all types in the genome, but its application is rather limited by the editing efficiency. …
Transcription factor NF-κB promotes acute lung injury
In the current study, we set out to decipher the convergence of miR-99b and p65 NF-κB activation in ALI pathology. We measured the release of pro-inflammatory cytokines (IL-1β, IL-6, and …
Methyltransferase-like 14 silencing relieves the development of ...
METTL14 interacted with p65, which influenced the apoptosis rates for ox-LDL-incubated HUVECs. (a) relative expression of p65 in HUVECs in the OE-NC and the OE-p65 groups …
Targeting CD133 reverses drug-resistance via the AKT/NF-κB
2020年3月16日 · The AKT OE plasmid or the NF-κB/p65 OE plasmid could reverse the effects of CD133 KD plasmid in LoVo/ADR cells: a reversal of reduced P-gp expression in western blots; …
CREB3 facilitates Donafenib resistance in hepatocellular carcinoma ...
Silencing of ZFAS1 or CREB3 enhanced the sensitivity of HCC cells to Donafenib, inhibited cell proliferation and IC 50, and increased cell apoptosis, which were reversed by p65 …