Although amines are good nucleophiles, we cannot use them is a direct SN 2 reaction to achieve the OH to NH 2 conversion because the hydroxide ion is a poor leaving group. So, the strategy for preparing an amine from an alcohol is first converting the OH into a good leaving group such as a mesylate, tosylate , or a halide , and then reacting ...

2013年1月17日 · For PhOH to PhNH2 Pd catalysis offers a better route than Zn reduction etc. Formation of the triflate by reaction with triflic anhydride then reaction under Pd catalysis with a source of N (I've used benzophenone imine or acetamide but there are others) then finally aqueous hydrolysis gets to the aniline in fairly respectable yield.

2023年1月23日 · A clear step toward improving the reactivity of alcohols in S N 2 reactions would be to modify the –OH functional group in a way that improves its stability as a leaving anion. One such modification is to conduct the substitution reaction in …

Halides are less reactive than sulfonate esters, however elimination as a competing side reaction is also reduced. - sulfonate esters can be converted to halides with the sodium halide in acetone at reflux. Chlorides are also converted to either bromides or iodides in the same fashion (Finkelstein Reaction). R O S O O R' R X X-

一步变成氨基只能是-oh——→-nh2，没什么好说的了。不过，α-羟基腈加氨就成了α-氨基腈，应该算是符合楼主的要求吧。

The Mitsunobu Reaction allows the conversion of primary and secondary alcohols to esters, phenyl ethers, thioethers and various other compounds. The nucleophile employed should be acidic, since one of the reagents (DEAD, diethylazodicarboxylate) must be protonated during the course of the reaction to prevent from side reactions.

Use a molar ratio of NH2/NCO ~ 0.5 to react only one of the NCOs. Use a solvent such as acetone or n-pyrrol at less than 60oC. The reaction of amines with isocyanate is fast and easy.

虽然O-H和N-H的区域重叠，但N-H吸收通常有一个或两个尖锐的低强度的吸收频带，而O-H在N-H的区域时，通常是一个宽的吸收峰，此外伯胺在这一区域有两个吸收峰。 胺基N-H与羟基O-H都在3300左右有吸收峰，并且都会缔合形成宽峰，如果谱图上有该处的峰，应该如何定性呢？ 是胺 …

Amines from Alcohols Via Substitution Reactions Although amines are good nucleophiles, we cannot use them is a direct SN2 reaction to achieve the OH to NH2 conversion because the hydroxide ion is a poor leaving group. So, the … Read more

吸电子吧，这些基团的是连在c上的，且电负性比c大，因此会从c上吸电子。-oh,-och3等基团连接在共轭体系中才可能表现为供电子。