2015年9月16日 · Lipopolysaccharide (LPS) subtypes also affect the levels of OMV production, as well as OMV cargo recruitment. OMV cargo may be enriched or excluded compared with its …

2025年1月6日 · We show that the removal of LPS enhances OMV’s intravenous tolerability of the OMV, thus enabling high-dose treatment for robust tumor suppression. Mechanistic …

2016年5月19日 · Here, we identify outer membrane vesicles (OMVs) produced by Gram-negative bacteria as a vehicle that delivers LPS into the cytosol triggering caspase-11-dependent …

来自康涅狄格大学的研究人员发现革兰氏阴性细菌产生的细胞外膜泡（outer membrane vesicles, OMVs）可作为载体递送LPS进入宿主细胞质，在体外和体内实验中触发caspase-11依赖性免 …

2021年8月25日 · Here, we report a ligand-receptor interaction-based OMV recruitment mechanism, consisting of a type VI secretion system (T6SS)-secreted lipopolysaccharide …

2021年4月6日 · Outer membrane vesicles (OMVs) can strongly activate the innate immune system and are qualified as immunoadjuvants. Here, we describe a versatile OMV-based …

2020年7月10日 · Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria both in vitro and in vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer …

2023年8月15日 · 先天免疫受体 TLR4 检测LPS和LOS，导致核因子-κB的激活和促炎反应（TLR4的激活可以通过大肠杆菌或铜绿假单胞菌MVs介导）；肠出血性大肠杆菌O157 MVs也 …

To alter properties of the outer membrane or evade the host immune response, Gram-negative bacteria employ a wide variety of chemical modifications to alter LPS. Here we review key …

2022年12月20日 · Outer membrane vesicles (OMVs) are non-living spherical nanostructures that derive from the cell envelope of Gram-negative bacteria. OMVs are important in bacterial …