The OPA1 gene provides instructions for making a protein that is found in cells and tissues throughout the body. The OPA1 protein is active in the inner membrane of cell structures …

2024年12月25日 · OPA1 (OPA1 Mitochondrial Dynamin Like GTPase) is a Protein Coding gene. Diseases associated with OPA1 include Behr Syndrome and Mitochondrial Dna Depletion …

2023年10月23日 · Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a role in cristae shaping. Disruption of OPA1 causes mitochondrial dysfunction. However, the role of OPA1 in …

Three major mouse models have been created to model OPA1 DOA: Opa1 +/del , Opa1 +/STOP , and Opa1 +/delTTAG . Zebrafish and Drosophila are also useful model organisms that have …

OPA1, a molecular regulator of dilated cardiomyopathy. OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response. Melatonin …

Optic atrophy type 1 is a condition that often causes slowly worsening vision, usually beginning in childhood. People with optic atrophy type 1 typically experience a narrowing of their field of …

2025年1月15日 · We found reduced expression of mitochondrial fusion–related genes, such as the dynamin-related guanosine triphosphatase (GTPase) optic atrophy 1 (OPA1), and …

2022年8月6日 · Optic atrophy 1 (OPA1) regulates IMM fusion, prevents apoptosis, and is a key regulator of morphological change in skeletal and cardiac muscle physiology and …

OPA1 is a dynamin-related GTPase that controls mitochondrial dynamics, cristae integrity, energetics and mtDNA maintenance. The exceptional complexity of this protein is determined …

In this review, we overview all recent findings on OPA1 protein functions, on its dysfunction and related clinical phenotypes, focusing on the current therapeutic options and future …