
Oncostatin M promotes cancer cell plasticity through cooperative STAT3 ...
2017年3月13日 · Of 28 TME cytokines and growth factors tested, we identified Oncostatin M (OSM) as the most potent inducer of mesenchymal/CSC properties. OSM-induced plasticity …
抑瘤素M (OSM): 白介素IL-6细胞因子家族成员,肿瘤、骨代谢、慢 …
对于OSM的转录和表达, STAT5 应答元件有重要作用, IL-2 、 IL-3 、 EPO 、 GM-CSF 等多种细胞因子能激活STAT5,从而使OSM高表达;前列腺素E2/ PG-E2 能上调OSM转录 [3-5]。 …
Oncostatin M promotes STAT3 activation, VEGF production, …
2011年4月11日 · These data indicate OSM stimulation of human and canine OSA cells induces STAT3 activation, thereby enhancing the expression/activation of MMP2 and VEGF, ultimately …
Activation of OSM-STAT3 Epigenetically Regulates Tumor …
2022年12月10日 · Deregulation of STAT3 is an oncogenic factor that promotes tumorigenesis and epithelial-to-mesenchymal transition (EMT) in various cancers. Oncostatin M (OSM), a …
Blocking Oncostatin M receptor abrogates STAT3 mediated …
2024年6月5日 · Using ectopic expression and knockdown approaches, we proved that OSMR directly regulates ITGAV and ITGB3 gene expression through STAT3 activation. Notably, …
Activation of OSM-STAT3 Epigenetically Regulates Tumor …
2022年12月10日 · Oncostatin M (OSM) induces Signal Transducer and Transcription 3 (STAT3) activation, exacerbating cervical cancer. The molecular mechanism by which the OSM-STAT3 …
Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 ... - PubMed
2021年10月15日 · Binding of OSM to OSMR caused OSMR-IL6ST dimerization, which is required to produce oncogenic signaling cues for prolonged STAT3 activation. Human monoclonal …
Oncostatin M: A mysterious cytokine in cancers - ScienceDirect
2021年1月1日 · STAT3 is the main downstream signaling molecule of OSM, which operates the leading role in modifications of cancer cells and enhancing cell growth, invasion, survival, and …
Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 …
2021年10月15日 · This study uncovers a role for OSMR in promoting ovarian cancer cell proliferation and metastasis by activating STAT3 signaling and demonstrates the preclinical …
STAT3-mediated SMAD3 activation underlies Oncostatin M …
2017年2月16日 · Our findings suggest that a novel STAT3/SMAD3-signaling axis is required for OSM-mediated senescence that is coopted during the transformation process to confer …