2017年3月13日 · Of 28 TME cytokines and growth factors tested, we identified Oncostatin M (OSM) as the most potent inducer of mesenchymal/CSC properties. OSM-induced plasticity …

对于OSM的转录和表达， STAT5 应答元件有重要作用， IL-2 、 IL-3 、 EPO 、 GM-CSF 等多种细胞因子能激活STAT5，从而使OSM高表达；前列腺素E2/ PG-E2 能上调OSM转录 [3-5]。 …

2011年4月11日 · These data indicate OSM stimulation of human and canine OSA cells induces STAT3 activation, thereby enhancing the expression/activation of MMP2 and VEGF, ultimately …

2022年12月10日 · Deregulation of STAT3 is an oncogenic factor that promotes tumorigenesis and epithelial-to-mesenchymal transition (EMT) in various cancers. Oncostatin M (OSM), a …

2024年6月5日 · Using ectopic expression and knockdown approaches, we proved that OSMR directly regulates ITGAV and ITGB3 gene expression through STAT3 activation. Notably, …

2022年12月10日 · Oncostatin M (OSM) induces Signal Transducer and Transcription 3 (STAT3) activation, exacerbating cervical cancer. The molecular mechanism by which the OSM-STAT3 …

2021年10月15日 · Binding of OSM to OSMR caused OSMR-IL6ST dimerization, which is required to produce oncogenic signaling cues for prolonged STAT3 activation. Human monoclonal …

2021年1月1日 · STAT3 is the main downstream signaling molecule of OSM, which operates the leading role in modifications of cancer cells and enhancing cell growth, invasion, survival, and …

2021年10月15日 · This study uncovers a role for OSMR in promoting ovarian cancer cell proliferation and metastasis by activating STAT3 signaling and demonstrates the preclinical …

2017年2月16日 · Our findings suggest that a novel STAT3/SMAD3-signaling axis is required for OSM-mediated senescence that is coopted during the transformation process to confer …