Mechanisms and therapeutic implications of cellular senescence in ...
2020年11月18日 · The development of osteoarthritis (OA) correlates with a rise in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) …
IF：81.3！从nature顶级子刊探索细胞衰老的关键特征：SASP - 知乎
Nature旗下顶级期刊 nature reviews molecular cell biology （IF：81.3） 于2024年发表了一项综述文章，系统讨论了SASP的组成、调控机制、动态变化及其异质性，并描述其在不同生理和病 …
衰老小课堂—SASP和细胞衰老 - 知乎 - 知乎专栏
细胞衰老是一种与不同细胞周期抑制剂（主要是 p16 和 p21）上调、结构和代谢改变、慢性 DNA 损伤反应以及称为衰老相关分泌表型 (SASP) 的过度分泌状态相关的终末生长停滞状态。 …
国际共识的细胞衰老标志物及检测方法，你get到了吗？ - 知乎
为推进细胞衰老领域快速发展，2019年，来自多个国家的细胞研究人员所成立的“ 国际细胞衰老学会 ”（International Cell Senescence Association, ICSA） 就细胞衰老的特征与生物标志物达 …
An immunosuppressive subtype of senescent tumor cells …
In this study, our objectives were to identify tumor-specific senescence-related genes to recognize STCs at the single-cell level and to investigate the heterogeneity of STCs in LUAD while …
指南共识 | 三个关于银屑病关节炎治疗推荐意见的总结及差别探讨
2022年11月9日 · 在ACR/NRF意见中将其称为口服小分子药物（Oral Small Molecules，OSM），包括甲氨蝶呤（MTX）、来氟米特（LEF）、柳氮磺吡啶（SASP）、 …
Overcoming the senescence‐associated secretory phenotype (SASP…
In this review, we will focus on recent evidence regarding therapy‐induced senescence (TIS) from anticancer agents, including chemotherapy, radiation, immunotherapy, and targeted therapies, …
Recent advances in senescence-associated secretory phenotype …
2024年2月29日 · The senescence-associated secretory phenotype (SASP), an essential cellular senescence hallmark, is an important mechanism connecting cellular senescence to …
Perspective: Targeting the JAK/STAT pathway to fight age …
The JAK pathway is more highly activate in senescent than non-senescent cells. Inhibition of the JAK pathway suppresses the SASP in senescent cells and alleviates age-related tissue …
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