Regulatory mechanisms orchestrating cellular diversity of - Cell Press
2024年9月24日 · Yang et al. utilized scRNA and scATAC sequencing approaches to characterize the cellular diversity of olfactory sensory neurons (OSNs). The study reveals a distinct OSN …
Transcriptional adaptation of olfactory sensory neurons to GPCR ...
2022年5月25日 · Our understanding of olfactory information coding is based on the expression of a single chemoreceptor gene, stochastically chosen from a single allele, in each olfactory …
嗅觉系统浅谈 - 知乎 - 知乎专栏
嗅球（olfactory bulb，OB）是嗅觉信息由OSN向脑传输进行信息处理的第一级。 嗅上皮中表达相同嗅觉受体的OSN会将轴突投射到同侧嗅球中同一嗅小球区域，进一步在嗅小球区域与40-50 …
Regulatory mechanisms orchestrating cellular diversity of
2024年9月24日 · In this study, we employed single-cell RNA sequencing (scRNA-seq) and single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) …
Single-cell transcriptomics reveals receptor transformations ... - Science
2015年11月5日 · Odor detection in mammals is mediated by odorant receptors on olfactory sensory neurons (OSNs) in the nasal olfactory epithelium (1, 2). In mice, ~1000 odorant …
Maturation of the Olfactory Sensory Neuron and Its Cilia - PMC
Basal progenitor cells of the olfactory epithelium transition into nascent OSNs marked by Cxcr4 expression and the initial extension of basal and apical neurites. Nascent OSNs become …
Nat Methods | 单细胞三维基因组与基因表达联合分析：北京大学 …
2024年4月17日 · 北京大学谢晓亮及斯坦福大学Longzhi Tan共同通讯在Nature Methods 在线发表题为“Simultaneous single-cell three-dimensional genome and gene expression profiling …
Regulatory Mechanisms Orchestrating Cellular Diversity in Cd36 ...
2023年9月22日 · Recent discoveries have revealed remarkable complexity and diversity within OSNs, including the existence of two distinct OSN populations based on high-affinity receptor …
Molecular events in the cell types of the olfactory epithelium …
2013年11月22日 · Background: Adult neurogenesis, fundamental for cellular homeostasis in the mammalian olfactory epithelium, requires major shifts in gene expression to produce mature …
Dishevelled proteins are associated with olfactory sensory neuron ...
Olfactory sensory neurons (OSNs) project their axons from the olfactory epithelium toward the olfactory bulb (OB) in a heterogeneous and unsorted arrangement. However, as the axons …